Perioperative Analgesia with Erector Spinae Plane Block in Liver Transplant Recipients

Not Applicable

Recruiting

• Conditions: Liver Transplant; Erector Spina Plan Block

• Registration Number: NCT06857331
• Lead Sponsor: Bogomolets National Medical University

Brief Summary

The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant. The main question it aims to answer are Is ESP block safe and has a minimum side effects, like hematoma? Is it effective for perioperative analgesia? Researchers will compare the results to a group of patients who underwent liver transplants without any regional anaesthesia techniques.

Participants will receive bilateral thoracic ESP block on the day of the transplantation with a subsequent bilateral catheterization.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-05
• Status Verified: 2025-02
• Study First Submitted: 2025-02-26
• Study First Submitted QC: 2025-02-26
• Last Update Submitted: 2025-02-26
• Study First Posted: 2025-03-04
• Last Update Posted: 2025-03-04
• Primary Completion: 2025-09-30
• Study Completion: 2025-12-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• impaired liver function - cirrhosis or chronic liver disease with the development of hypocoagulation (APTT > 35 sec, INR > 1.5), thrombocytopenia, patients requiring major abdominal surgery, age > 18 years, written consent to participate in the study was obtained

Exclusion Criteria

• Platelet count <50x109, failed ESP catheterization unilateral or bilateral, failed epidural anesthesia attempt, history of allergy or hypersensitivity to local anesthetics, hepatopulmonary syndrome, patients on mechanical ventilation before surgery, patients on CRRT before surgery, refusal to participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Pain reduction postoperative	from enrollment to the 2nd postoperative day	Pain assessment with scores
Opioid reduction intraoperatively	from enrollment to the end of the operation	The amount of intraoperative fentanyl
Need for opioids postoperatively	from enrollment to the 2nd postoperative day	Need for opioids postoperatively

Trial Locations

Locations (1)

Universal Hospital Oberig; 🇺🇦 Kyiv, Ukraine