A Study of SCAD Using Stress Contrast Echocardiography

Not yet recruiting

• Conditions: Spontaneous Coronary Artery Dissection

• Registration Number: NCT07178509
• Lead Sponsor: Mayo Clinic

Brief Summary

This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-02
• Study First Submitted QC: 2025-09-10
• Last Update Submitted: 2025-09-10
• Study First Posted: 2025-09-17
• Last Update Posted: 2025-09-17
• Study Start: 2025-10-01
• Primary Completion: 2027-09
• Study Completion: 2027-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adult >18 years old
• Patient has a history of spontaneous coronary artery dissection (SCAD) OR patient is healthy with no significant medical history

Exclusion Criteria

• Unable to give consent
• Allergic or have a history of adverse reaction to dobutamine, the Definity® ultrasound enhancing agent, or atropine.
• Has a known or suspected hypersensitivity to perflutren and therefore cannot be given Definity®.
• Pregnant.
• Unable to interrupt breastfeeding.
• Within 3 months of a heart attack.
• Severe aortic stenosis.
• Severe, uncontrolled hypertension (>200/110 mmHg at baseline).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Microvascular Function	Baseline, immediately after the Stress Echocardiography	Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation.
Change in Blood Pressure	Baseline, immediately after the Stress Echocardiography	Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg).
Change in Heart Rate	Baseline, immediately after the Stress Echocardiography	Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute).

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States