Revascularisation of Autotransplanted Teeth
Not Applicable
Completed
- Conditions
- Pulp Canal ObliterationEndodontic Disease
- Registration Number
- NCT05267249
- Lead Sponsor
- Medical University of Graz
- Brief Summary
Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection
Note: The study was registered on Clinicaltrials.gov after termination of study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Male and female consenting and judicious young people and adults
- Written consent of the participant and, if applicable, of the legal guardian after education
- Planned tooth transplantation with advanced or completed root growth
Exclusion Criteria
- Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw)
- Current or past antiresorptive therapy with bisphosphonates
- Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases
- Acute gingivitis or advanced periodontitis
- Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors)
- heavy smokers (> 10 per day)
- Acute or chronic infections (osteomyelitis) at the surgical site
- metabolic diseases (diabetes, hyperparathyroidism, osteomalacia)
- Severe kidney dysfunction, severe liver disease
- Patients with high-dose corticosteroid therapy
- prolonged corticosteroid or radiotherapy in the oral cavity
- autoimmune diseases
- Pregnant or breastfeeding women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Survival 1 year Tooth survival
- Secondary Outcome Measures
Name Time Method Revascularisation 1 year Occurrence of Revascularisation
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie successful revascularization in autotransplanted teeth with pulp canal obliteration?
How does revascularization of autotransplanted teeth compare to conventional endodontic treatments for pulp canal obliteration in long-term outcomes?
Are there specific biomarkers that indicate successful revascularization outcomes in autotransplanted teeth post-root end resection?
What are the potential adverse events associated with autotransplantation and revascularization techniques in mature teeth?
What combination therapies or novel approaches are being explored alongside revascularization for endodontic disease management?
Trial Locations
- Locations (1)
Medical University of Graz
🇦🇹Graz, Styria, Austria
Medical University of Graz🇦🇹Graz, Styria, Austria