Dexamethasone for ESPB in Total Hip Arthroplasty

Phase 4

Recruiting

• Conditions: Hip Osteoarthritis; Hip Arthropathy; Hip Arthritis
• Interventions: Drug: 0.9%NaCl; Drug: Dexamethasone 4mg

• Registration Number: NCT06789042
• Lead Sponsor: Poznan University of Medical Sciences

Brief Summary

Effect of adding Dexamethasone to Erector Spinae Plane Block in Patients undergoing Total Hip Arthroplasty

Detailed Description

Hip arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Study Timeline

• Study First Submitted: 2025-01-17
• Study First Submitted QC: 2025-01-17
• Study First Posted: 2025-01-23
• Study Start: 2025-02-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-20
• Last Update Posted: 2025-03-24
• Primary Completion: 2025-07-01
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• patients scheduled for total hip arthroplasty
• patients aged >65 and <100 years
• patients able to provide informed consent
• patients able to reliably report symptoms to the research team

Exclusion Criteria

• inability to provide first-party consent due to cognitive impairment or a language barrier

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	0.9%NaCl	Ultrasound-guided ESPB - 20ml 0,2% ropivacaine + 2ml 0.9% NaCl
Dexamethasone	Dexamethasone 4mg	Ultrasound-guided ESPB - 20ml 0,2% ropivacaine + 4mg Dexamethasone

Primary Outcome Measures

Name	Time	Method
Time to first rescue opioid analgesia	48 hours after surgery	Time after surgery when the patient needs opiate for the first time

Secondary Outcome Measures

Name	Time	Method
Nerve damage [range 0-4]	48 hours after surgery	Nerve damage assesment will be performed using the nerve damage score (N0- no nerve damage; N1- minor - sensory paresthesia; N2- major -complete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome)
blood glucose	48 hours after surgery	blood glucose levels
Total Opioid Consumption	48 hours after procedure	otal opiate consumption after surgery
Numerical Rating Scale [range 0:10]	48 hours after surgery	Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)
Quadriceps muscle strength assessed using medical research council scale [range 0:5]	48 hours after surgery	Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating

Trial Locations

Locations (1)

Poznan University of Medical Sciences; 🇵🇱 Poznan, Wielkopolska, Poland