Serotonin transporter gene variation and sensitivity to conditioned cues: cause and cure in cocaine dependence

Completed

Conditions: verslaving
cocaine addiction

Registration Number: NL-OMON40013

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 140

Inclusion Criteria

Male subjects with cocaine dependence as defined in the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition (DSM-IV; American Psychiatric Association 1994), and will be determined by a structured interview (Composite International Diagnostic Interview: CIDI) aged 18-40 years. Controls: male healthy volunteers aged 18 - 50 years.

Exclusion Criteria

No cocaine dependence Positive DSM-IV/CIDI for any drug other than cocaine, heroin, alcohol or marijuana Major neurological disorders, claustrophobia, peripheral vascular diseases, current use of respiratory, cardiovascular, anticonvulsant or psychoactive medications (SSRIs), or alexithymia A positive urine test result for amphetamines, barbiturates, benzodiazepine metabolites, cocaine (metabolite), opiates, alcohol, and marijuana

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- MRI: volume (mL) of all ROIs <br /><br>- DTI: FA values within all ROIs <br /><br>- BOLD: % change in BOLD signal within all ROIs, during fMRI tasks that assess<br /><br>emotional and rewardprocessing, fear conditioning and drug-cue reactivity<br /><br>- BOLD: % change in BOLD signal within all ROIs during a cue-reactivity task <br /><br>- 1H-MRS: resting state glutamate concentration in ACC and PFC (per voxel:<br /><br>glutamate/CSF) <br /><br>- VAS: % change in VAS-scores for craving elicited by drug-related cues <br /><br><br /><br><br /><br><br /><br>In all analysis, the ROIs are the vmPFC, the OFC, the ACC and the amygdala.<br /><br><br /><br> For these outcome measures the main study parameters are the difference<br /><br>between genotypes (s- or l-allele) and group (healthy controls or cocaine<br /><br>dependent patients)<br /><br><br /><br>* For these outcome measures, the influence of the 5 other polymorphisms will<br /><br>be investigated in a exploratory analysis. </p><br>

Secondary Outcome Measures