Hormonal Stimulation in IUI Treatment: Is Clomifen Combined With Ethinyl Estradiol Better, Worse or Equal to Menopur

Not Applicable

Completed

• Conditions: Subfertility
• Interventions: Drug: Menotropins; Drug: Clomifen, Ethinyl Estradiol

• Registration Number: NCT01569945
• Lead Sponsor: University Hospital, Gasthuisberg

Brief Summary

What is the best medication for hormonal stimulation in cycles with high intra-uterine insemination: tablets of Clomifen (5 days) followed by tablets of Ethinyl Estradiol (5 days) or daily injections with Human Menopausal Gonadotropin (Menopur)?

Detailed Description

Not available

Study Timeline

• Study Start: 2004-09
• Primary Completion: 2010-12
• Study Completion: 2011-12
• Study First Submitted: 2012-03-28
• Study First Submitted QC: 2012-03-30
• Study First Posted: 2012-04-03
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-09
• Last Update Posted: 2014-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 371

Inclusion Criteria

• women younger than 42 years old
• infertility of at least one year
• normal tubal, pelvic and uterine anatomy
• semen with total motility count of at least 5 million (at least one sample)

Read More

Exclusion Criteria

• premature ovarian failure
• medical history of tubal or ovarian surgery
• tubal or pelvic adhesions

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
human menopausal gonadotropins	Menotropins	Daily Injections
Tablets	Clomifen, Ethinyl Estradiol	Clomifen (5 days) followed by Ethinyl Estradiol (5 days)

Primary Outcome Measures

Name	Time	Method
pregnancy rate	on average 30 days if not pregnant and 12 weeks if pregnant

Trial Locations

Locations (1)

Leuven University Fertility Center; 🇧🇪 Leuven, Vlaams Brabant, Belgium