ACTRN12615000635561已完成4 期
The effect of canakinumab adjunctive treatment on symptoms and cognition in people with schizophrenia displaying elevated peripheral inflammatory markers
euroscience Research Australia0 个研究点目标入组 30 人开始时间: 2015年6月18日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 55 Years（—）
- 性别
- All
入选标准
- •diagnosis of schizophrenia or schizoaffective disorder
- •between 18 and 55 years of age
- •have been receiving antipsychotic medication for at least 1 year
- •display elevated neutrophil to lymphocyte ratio greater than 2 or
- •an elevated IL-1beta ELISA assay
排除标准
- •concurrent DSM-V axis I psychiatric diagnosis other than schizophrenia or schizoaffective disorder
- •display a neutrophil to lymphocyte ratio less than 2 or
- •display normal IL-1beta ELISA levels
- •history of current substance abuse or dependence (within the past 3 years)
- •head injuries with loss of consciousness
- •central nervous system infection
- •untreated diabetes or hypertension
- •mental retardation
- •learning disorder
- •history of pervasive developmental disorder
- •present systemic infections
- •history of recurrent infections
- •have been recently administered live vaccines
- •neutropenia (defined by neutrophil count)
- •positive pregnancy blood test
- •intends to become pregnant
- •refuses to use contraception or remain abstinent till 1 month after the study
- •history of causing harm to self or others
- •receiving tumor necrosis factor inhibitors
- •receiving clozapine
- •hypersensitivity or contraindications to canakinumab
研究者
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