Investigating Baseline Cortical Haemodynamics in Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Cerebral Blood Flow
研究概览
简要总结
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease. It will also instruct us as to the most effective scanning protocols for future research. Developing a suitable protocol for studying perfusion longitudinally may also enable identification of new therapeutic interventions to normalise any perfusion abnormalities in MS patients.
详细描述
We aim to characterise the underlying cortical haemodynamics in Multiple Sclerosis (MS). We will assess two techniques for measuring blood flow in the brain: arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging in the MS patient group. ASL is a non-invasive technique whilst DSC-MR requires the administration of a tracer intravenously. Previous studies have shown conflicting results from these measurements. Reproducibility of ASL and disease activity will also be assessed through repeated scan sessions. Global perfusion in the MS patient group will be compared to a matched healthy control group.
In addition to measuring blood flow using both methods, we will investigate whether differences in perfusion between the MS patient group and the healthy controls can be observed using ASL, and also assess the reproducibility of ASL measurements via repeated scans. These repeated scanning sessions also provide a window to study disease activity in the patient cohort, and patients may be invited to return for up to a total of 4 scanning sessions (with only one involving the use of DSC) to better assess the usefulness of ASL in tracking haemodynamic changes in MS.
Study Regimen:
We aim to recruit 20 MS patients and 20 healthy age-matched controls for this study.
MS Patient Cohort:
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Any history of neurological illness other than MS.
- •Known hypersensitivity to any MR or X-Ray contrast agent.
- •Any history of renal failure or disease.
- •Any history of allergies.
- •Any history of circulation problems (vascular disease).
- •Pregnancy or breastfeeding.
- •MRI contraindications as screened on safety questionnaire (e.g. metal implants or pacemaker).
- •Have taken part in any other clinical study within the previous 3 months.#
- •Any contraindications provided from MRI or contrast agent safety forms.
研究组 & 干预措施
Healthy Volunteers
Healthy Volunteers will undergo an Magnetic Resonance Imaging scan.
干预措施: Magnetic Resonance Imaging (Device)
MS Patients
Patients will undergo and Magnetic Resonance Imaging scan including the use of Prohance (Gadoteridol).
干预措施: Magnetic Resonance Imaging (Device)
MS Patients
Patients will undergo and Magnetic Resonance Imaging scan including the use of Prohance (Gadoteridol).
干预措施: Prohance (Gadoteridol) (Drug)
结局指标
主要结局
Cerebral Blood Flow
时间窗: 1 hour
A short MRI scan is able to quantify the amount of blood perfusion into brain tissue (to be performed with and without the gadolinium contrast agent).
次要结局
- Arterial Cerebral Blood Volume(1 hour)
- Arterial Transit Time(1 hour)