Does buprenorphine 0.3 mg prolongs the analgesic effect of a blockade of the femoral nerve with ropivaciane 0.2% for patients with a total knee replacement. A prospective triple-blinded placebo-controlled RCT?
- Conditions
- anaesthesie, pijnbehandelingpain perceptiontotal knee replacement.
- Registration Number
- NL-OMON37162
- Lead Sponsor
- Westfries Gasthuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 63
18-80 years.
Elective total knee replacement,
Fever, temperature higher than 37.5 degrees Celsius (orthopedic surgery don*t proceed)
Allergy to local anesthetics
Allergy to buprenorphine
pregnancy
Opiate use pre existent for surgery,
Infection of the skin at the area of the needle insertion opening in favor of Vagus femoralisblokkade.
Revision surgery of the knee.
General anesthesia instead of spinal anesthesia.
If patient is not under full anesthetic protocol policy for prosthetic hip and knee surgery.
EGFR <50 ml per minute.
Allergy to Non Steroid Anti Inflammatory Drugs (NSAIDS).
If pre-operative 10cm above the patella in the midline there is no left versus right difference in cold sensation than ithe block is tittled not sufficient and the patient will be removed from the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Does 0.3 mg of buprenorphine as an additive in femoral nerve blockade prolongs<br /><br>analgesia?</p><br>
- Secondary Outcome Measures
Name Time Method
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