ISRCTN46158146
已完成
未知
A randomised trial to compare the safety, tolerability and efficacy of bi-monthly intermittent preventive treatment with either artesunate plus mefloquine or amodiaquine plus sulfadoxine-pyrimethamine with the standard regimen of daily proguanil for the prevention of malaria and related complications in patients with sickle cell anaemia in Nigeria
Wellcome Trust (UK)0 个研究点目标入组 270 人2011年11月14日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- 未指定
- 发起方
- Wellcome Trust (UK)
- 入组人数
- 270
- 状态
- 已完成
- 最后更新
- 7年前
概览
简要总结
2015 results in: https://www.ncbi.nlm.nih.gov/pubmed/25701866
研究者
入排标准
入选标准
- •1\. Age 6months or older and \>\=5kg
- •2\. Sickle cell clinic attendant
- •3\. Both males and females
- •4\. Agree to abide by the study protocol
- •5\. Give informed consent and assent
- •6\. Not acutely sick at the time of recruitment
- •7\. Not having additional chronic disease
- •8\. Haemoglobin (Hb) genotype of SS and SC confirmed by electrophoresis
排除标准
- •1\. Known allergy to any of the antimalarial drugs use in the trial
- •2\. Severe illnesses requiring urgent admission
- •3\. Treatment with sulfadoxine\-pyrimethamine or mefloquine in the previous 2 weeks
- •4\. Patients on cotrimoxazole prophylaxis
结局指标
主要结局
未指定
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