Precision Radiotherapy for Tumours Using Magnetic Resonance-guided Linear Accelerator (MR-Linac)

Recruiting

• Conditions: Overall Response Rate; Radiation Toxicity; Oncology; Quality of Life

• Registration Number: NCT06531681
• Lead Sponsor: The Second Affiliated Hospital of Hainan Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-6-28
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

Inclusion Criteria:<br><br> - Patients are undergoing or have undergone imaging or treatment at the MR linac;<br><br> - Age 18-75 years, male or female;<br><br> - ECOG score 0-2, life expectancy > 6 months;<br><br> - Patients provide written informed consent.<br><br>Exclusion Criteria:<br><br> - Contraindications to MRI, such as claustrophobia and metallic or electronic implants<br> incompatible with MRI;<br><br> - The presence of severe comorbidities that, in the opinion of the investigator, ·<br> preclude the toleration or completion of radiotherapy;<br><br> - Acute inflammatory disease requiring systemic therapy;<br><br> - The presence of active infectious disease;<br><br> - Pregnant women, nursing mothers, and patients planning to have children during the<br> study period.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
overall response rate

Secondary Outcome Measures

Name	Time	Method
Progression-Free Survival;Disease Control Rate;Overall survival;Incidence of adverse reactions;Patient reported Health related quality of life (HRQoL);Dosimetric parameters:dose of target volume(TV);Dosimetric parameters:OAR;Dosimetric parameters:? passing rate