Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Change from baseline in cerebrovascular reactivity
研究概览
简要总结
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A single ischemic stroke with Middle cerebral artery (MCA) stenosis
- •Men or women age 50-80 years
- •Physician's approvals to participate the study
- •Stroke experienced at least 7 days of ischemic stroke onset and no more than 6 months before study enrollment
- •The modified rankin scale level is 2 or 3
排除标准
- •History of serious diseases
- •Musculoskeletal diseases (Chronic arthritis, Lower spondylosis/spondylolisthesis with radiculopathy, Spinal deformity, Cervical spondylosis, Rheumatoid arthritis)
- •Cardiovascular diseases (Poorly control hypertension, Heart disease class C and D)
- •Neurological disorders (Peripheral neuropathy, Parkinson)
- •Respiratory diseases (Chronic Obstructive Pulmonary Disease)
- •Brain disorders (Cardioembolic, Severe dementia, Alzheimer's disease)
- •Medical condition precluding taking Anticoagulant and Statin drug
- •Temporal window were not found
结局指标
主要结局
Change from baseline in cerebrovascular reactivity
时间窗: baseline, Post-test (immediately: 0 min after finish massage intervention, 60 min, 120 min, 24 Hrs.
\- Cerebrovascular reactivity or cerebral CO2 reactivity test will be assessed using the ultrasound equipment (CX50, Philips, USA). Blood flow velocity (BFV) of the middle cerebral artery (MCA) will be measured during normocapnic, hypocapnic, and hypercapnic states. Subjects will be asked to wear nose clips and breathe only through a mouthpiece. Baseline (3 minutes) recordings will be taken during spontaneous breathing of room air and then subjects underwent 1 minute of maximal voluntary hyperventilation with a duty cycle of 1 second. The MCA-BFV will be recorded during the last 20 seconds of hyperventilation. After that, subjects will be asked to breathe air containing a mixture of 5 % CO2 and 21 % O2 balanced with nitrogen spontaneously for 3 minutes and the MCA-BFV will be recorded during the last minute of hypercapnia.
次要结局
- Change from baseline in blood chemistry(baseline, Post-test (immediately: 0 min after finish massage intervention))
- Change from baseline in stress indicators(Baseline, Post-test (immediately: 0 min after finish massage intervention, 60 min, 120 min, 24 Hrs.)
- Change from baseline in Peripheral arterial stiffness(Baseline, Post-test (immediately: 0 min after finish massage intervention, 60 min, 120 min, 24 Hrs.)
研究者
Assoc. Prof. Dr.Daroonwan Suksom
DSuksom
Chulalongkorn University