Finistere Myeloma Observatory (OMYFIN)

Completed

• Conditions: Multiple Myeloma

• Registration Number: NCT06552221
• Lead Sponsor: University Hospital, Brest

Brief Summary

Current molecular risk stratification of multiple myeloma (MM), based on the presence of t(4 ;14) and 17p deletion, cannot fully explain treatment outcome heterogeneity, as other features also predict prognosis. About 30% of genetic events map to chromosome 1 : most upregulated genes to 1q and most downregulated ones to 1p. CKS1B gains on 1q21 and CDKN2C loss on 1p32, both favoring cell cycle progression, portended impaired outcome in many but not all studies. Based on their recurrence and considering their functional convergence, we hypothesized CKS1B/CDKN2C copy number ratio to be a risk factor fitter than each aberration alone.

Detailed Description

This single-center retrospective study, is designed to enroll all consecutive newly diagnosed adult patients aged ≥18 years, transplant-eligible and not. All patients are routinely tested for CKS1B and CDKN2C and treated according to consensus guidelines. Data are being collected from 2012. For each subject, we calculate a FISH-based ratio by CKS1B on CDKN2C copy number : it is equal to 1 with no change in copy number and \>1 in case of CKS1B gains, CDKN2C loss or both. In patients with CDKN2C biallelic loss, the ratio is not equal to 0, but to CKS1B copy number, as functional consequence should prevail over arithmetic result. We will, then, analyze separately the impact of CKS1B gains, CDKN2C loss and CKS1B/CDKN2C ratio on PFS and OS.

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2022-12-15
• Study Completion: 2023-06-30
• Status Verified: 2024-08
• Study First Submitted: 2024-08-09
• Study First Submitted QC: 2024-08-09
• Last Update Submitted: 2024-08-09
• Study First Posted: 2024-08-13
• Last Update Posted: 2024-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Age at or over 18 years
• Symptomatic multiple myeloma
• Informed consent given
• FISH-based cytogenetic results obtained

Exclusion Criteria

• Age under 18 years
• MGUS or SMM
• No informed consent
• No FISH-based cytogenetic results

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response rate	10 years	The aim is to assess the impact of CKS1B/CDKN2C copy number ratio on response rate

Secondary Outcome Measures

Name	Time	Method
Progression-free survival (PFS)	10 years	The aim is to assess the impact of CKS1B/CDKN2C copy number ratio on PFS

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France