Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD

Recruiting

• Conditions: Chronic Obstructive Pulmonary Disease

• Registration Number: NCT06275230
• Lead Sponsor: China-Japan Friendship Hospital

Brief Summary

The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:

* Can human lung stem cell proliferate in vitro.

* Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-02-17
• Study First Submitted QC: 2024-02-22
• Study First Posted: 2024-02-23
• Study Start: 2024-03-20
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-07
• Last Update Posted: 2025-02-10
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1. Age under 55, regardless of gender
• 2. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy
• 3. No genetic diseases and other respiratory diseases

Exclusion Criteria

• Other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of Patients completed bronchoscope.	1 day

Trial Locations

Locations (1)

China-Japan Friendship Hospital; 🇨🇳 Beijing, Beijing, China