Airway Management During TCI vs RSI Anesthesia Induction

Completed

• Conditions: Airway Complication of Anesthesia; Adverse Effect; Anesthesia

• Registration Number: NCT03723109
• Lead Sponsor: Umeå University

Brief Summary

The aims of this observational study is to evaluate and compare feasibility of airway management during standardized TCI and RSI anesthesia induction.

Detailed Description

The aims of this study are to evaluate and compare feasibility of airway management and risk for desaturation during standardized target controlled infusion (TCI) and rapid sequence induction (RSI) of anesthesia. A conventional way to induce anesthesia, i.e. manual injection of anesthetics, may be more accurate and predictable compared to dosing regimes based on complex mathematical algorithms used in TCI-systems. In addition, today many different models are presented and there is no consensus which kind of TCI-algorithm should be used universally. Moreover, dosing algorithms are most complex and challenging in underweight and morbid obesity. There are many publications on this field, but no data of feasibility of airway management can be found. Indeed, RSI induction is traditionally blamed to be risky and not recommended as a first choice.

Study Timeline

• Study First Submitted: 2018-10-25
• Study First Submitted QC: 2018-10-26
• Study Start: 2018-10-29
• Study First Posted: 2018-10-29
• Primary Completion: 2019-02-22
• Study Completion: 2019-05-31
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-25
• Last Update Posted: 2019-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• signed informed consent
• BMI < 35 kg/m2
• preoperative assessment accepted by consultant anesthesiologist
• scheduled for breast cancer surgery, endocrinological surgery (thyroid, parathyroid) or minor general abdominal surgery.

Exclusion Criteria

• not signed consent
• instable angina pectoris
• severe bronchial asthma
• severe chronic obstructive pulmonary disease
• dementia
• severe heart valve disease
• severe renal failure
• body mass index > 35 kg/m2

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Safety time for apnea	10min	measurement of length of period for apnea during TCI and RSI induction by a timer

Secondary Outcome Measures

Name	Time	Method
Duration of spontaneous breathing	10min	measurement of duration of spontaneous breathing during TCI and RSI induction by a timer

Trial Locations

Locations (1)

Sunderby teaching hospital; 🇸🇪 Luleå, Sweden