Implementation of an upgraded strategy to reach zero HIV transmission by breastfeeding in Zambia: The PROMISE-ZERO study
Phase 4
- Conditions
- HIV/AIDSPaediatrics
- Registration Number
- PACTR202407898537403
- Lead Sponsor
- niversity Teaching Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 2100
Inclusion Criteria
The mother/infant pairs must meet the following criteria:
- Mother living with HIV attending the EPI-2 visit
Or
-Mother diagnosed with HIV after EPI-2 visit while she is still breastfeeding
And
- Breastfed infant
- Mother aged 15 years or above
Exclusion Criteria
- Infant having a known allergy to the study drug or its components
- Infant with a diagnosis of HIV infection at the time of inclusion
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie HIV transmission prevention during breastfeeding in the PROMISE-ZERO trial?
How does the upgraded strategy in PROMISE-ZERO compare to standard ART in reducing HIV transmission via breastfeeding?
Which biomarkers predict successful HIV transmission prevention in breastfeeding mothers using the PROMISE-ZERO protocol?
What adverse events are associated with the PROMISE-ZERO breastfeeding HIV prevention strategy and their management?
Are there combination therapies with existing antiretrovirals like tenofovir that enhance breastfeeding HIV transmission prevention in Zambia?