Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis

Phase 2

• Conditions: Chronic Periodontitis
• Interventions: Procedure: scaling and root planing; Procedure: Frankincense extract gel natural herbal product

• Registration Number: NCT05005767
• Lead Sponsor: Tanta University

Brief Summary

This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.

Detailed Description

: twenty patients will be randomly selected and equally divided into Group I: will receive SRP only, group II: will receive SRP and Frankincense extract the gel. Subgingival application of Frankincense extract gel will be performed following initial SRP )day 1) and at 7, and 14 days. Clinical measurements included pocket depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). Real-time PCR was carried out to determine the effect of the treatment on Porphyromonas gingivalis (Pg). Clinical measurements and Plaque samples for PCR were recorded at baseline (before treatment), one, and three months after treatment.

Study Timeline

• Study Start: 2021-04-01
• Study First Submitted: 2021-07-31
• Status Verified: 2021-08
• Study First Submitted QC: 2021-08-10
• Last Update Submitted: 2021-08-10
• Study First Posted: 2021-08-16
• Last Update Posted: 2021-08-16
• Primary Completion: 2021-11
• Study Completion: 2022-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• systemically healthy patients were selected
• patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing.
• Patients should demonstrate their ability to maintain good oral hygiene

Exclusion Criteria

• Smokers and pregnant patients.
• Medically compromised patients and systemic conditions precluding periodontal surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
test group	Frankincense extract gel natural herbal product	Ten patients with sites suffering from mild chronic periodontitis. sites will be treated with scaling and root planing (SRP) and subgingival application of Frankincense extract gel
test group	scaling and root planing	Ten patients with sites suffering from mild chronic periodontitis. sites will be treated with scaling and root planing (SRP) and subgingival application of Frankincense extract gel
Placebo group	scaling and root planing	ten patients with sites suffering from mild chronic periodontitis sites will be treated with scaling and root planing (SRP) only

Primary Outcome Measures

Name	Time	Method
bleeding on probing	3 month	bleeding on probingwill be recorded at 3 months at the site to be treated
clinical attachment level	3 month	clinical attachment level will be recorded at 3 months at the site to be treated
probing pocket depth	3 month	probing pocket depth will be recorded at 3 month at the site to be treated
PCR for Porphyromonas gingivalis count	3 month	PCR for Porphyromonas gingivalis count be recorded at 3 months at the site to be treated

Trial Locations

Locations (1)

Doaa Ahmed yousef bayoumi; 🇪🇬 Tanta, Gharbiya, Egypt