The Adjunctive Effect of Frankincense Extract Gel on Non-Surgical Treatment of Chronic Periodontitis: Clinical and Microbiological Study.
试验速览
- 阶段
- 2 期
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- bleeding on probing
研究概览
简要总结
This study will evaluate the effect of the subgingival application of Frankincense extract gel as an adjunct to scaling and root planning (SRP) in chronic periodontitis.
详细描述
: twenty patients will be randomly selected and equally divided into Group I: will receive SRP only, group II: will receive SRP and Frankincense extract the gel. Subgingival application of Frankincense extract gel will be performed following initial SRP )day 1) and at 7, and 14 days. Clinical measurements included pocket depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). Real-time PCR was carried out to determine the effect of the treatment on Porphyromonas gingivalis (Pg). Clinical measurements and Plaque samples for PCR were recorded at baseline (before treatment), one, and three months after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •systemically healthy patients were selected
- •patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing.
- •Patients should demonstrate their ability to maintain good oral hygiene
排除标准
- •Smokers and pregnant patients.
- •Medically compromised patients and systemic conditions precluding periodontal surgery.
结局指标
主要结局
bleeding on probing
时间窗: 3 month
bleeding on probingwill be recorded at 3 months at the site to be treated
clinical attachment level
时间窗: 3 month
clinical attachment level will be recorded at 3 months at the site to be treated
probing pocket depth
时间窗: 3 month
probing pocket depth will be recorded at 3 month at the site to be treated
PCR for Porphyromonas gingivalis count
时间窗: 3 month
PCR for Porphyromonas gingivalis count be recorded at 3 months at the site to be treated
次要结局
未报告次要终点
研究者
Doaa Ahmed Yousef
lecturer at Periodontology, oral medicine, diagnosis and radiology department
Tanta University