Expression of Programmed Death -Ligand 1 (PD-L1) and CD8 in oral squamous cell carcinoma and its association with clinicopathological parameters
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Proportion of cases of oral squamous cell carcinoma showing PD-L1 and CD8 expression
研究概览
简要总结
Oral cancers constitute roughly one-fourth of global occurrences. Most common histological subtype is oral squamous cell carcinoma. PD-L1 is expressed on antigen presenting cells , it causes T cell to undergo apoptosis, so PD-L1 binding to PD-L1 receptors on T cells can suppress antitumor immune responses. Tumor grade and prognosis are associated with PD-L1 expression. Tumor infiltrating CD8+lymphocytes (TILs), play a role in the host’s immunological response to Tumor cells.
There is paucity of studies in Indian literature on the expression of Programmed Death Ligand (PD-L1) and CD8 in oral squamous cell carcinoma and its association with clinicopathological parameters.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All the newly diagnosed cases of primary oral squamous cell carcinoma whose samples are received in the Department of Pathology,MAMC 2) Age more than 18 years.
排除标准
- •Patients who have received radiotherapy and/or chemotherapy.
- •Patients having previous history of any other malignancy.
结局指标
主要结局
Proportion of cases of oral squamous cell carcinoma showing PD-L1 and CD8 expression
时间窗: Baseline
次要结局
- Association between expression of PD-L1 and CD8 with clinicopathological parameters like age, Sex, duration of symptoms, tumor size, location, grade, stage, metastasis, lympho-vascular invasion, perineural invasion.(Baseline)
研究者
Dr Pragya Nandini
Maulana Azad Medical college