Executive Function in Preterm Born Children: An Integrative Approach From Genetics to Brain Function

• Conditions: Preterm Infants
• Interventions: Other: MRI, EEG and cognitive testing

• Registration Number: NCT01615523
• Lead Sponsor: University of Zurich

Brief Summary

Hd-EEG and MRI measures are used to study the maturation of functional networks in order to identify the neural circuits underlying executive and memory processes in children born preterm. It will be determined whether children born preterm with executive function deficits will have an abnormal connectivity between basal ganglia and cortex due to WM injury. Moreover, the development of hd-EEG activity during sleep (coherence and travelling waves) and brain maturation of children and adolescents born preterm will be compared with the respective measures in healthy controls. This is of eminent importance as it helps to understand the nature of executive function and hence, it may help to develop neuroprotective strategies to prevent executive function deficits in these infants.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2012-06
• Study First Submitted: 2012-06-06
• Study First Submitted QC: 2012-06-07
• Last Update Submitted: 2012-06-07
• Study First Posted: 2012-06-08
• Last Update Posted: 2012-06-08
• Study Start: 2012-09
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Children/adolescents born preterm	MRI, EEG and cognitive testing	-
Control children and adolescents	MRI, EEG and cognitive testing	-

Trial Locations

Locations (1)

University Hospital Zurich, Division of Neonatology; 🇨🇭 Zurich, ZH, Switzerland