Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Not Applicable

• Conditions: Irritable Bowel Syndrome

• Registration Number: NCT00742118
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:

1. paracellular permeability in colonic biopsies of IBS patient

2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2008-08-26
• Study First Submitted QC: 2008-08-26
• Study First Posted: 2008-08-27
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-29
• Last Update Posted: 2015-09-30
• Primary Completion: 2016-02
• Study Completion: 2016-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients needing coloscopy

Exclusion Criteria

• Disrupted coagulation results
• Cancer even healed
• Known food allergy.
• Alcohol consumption >30g/day

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Inflammation molecule expression	at time=0
Gap junction protein expression	at time=0
Para-cellular permeability	at time=0
Digestive discomfort degree	at time=0

Trial Locations

Locations (1)

Department of gastroenterology, Hopital Archet 2; 🇫🇷 Nice, France