Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel
Not Applicable
- Conditions
- Irritable Bowel Syndrome
- Interventions
- Procedure: Colic biopsies
- Registration Number
- NCT00742118
- Lead Sponsor
- Centre Hospitalier Universitaire de Nice
- Brief Summary
Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:
1. paracellular permeability in colonic biopsies of IBS patient
2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Patients needing coloscopy
Exclusion Criteria
- Disrupted coagulation results
- Cancer even healed
- Known food allergy.
- Alcohol consumption >30g/day
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 3 Colic biopsies patient having no symptoms 2 Colic biopsies patient with chronic inflammatory intestinal disease 1 Colic biopsies patient with irritable bowel syndrome
- Primary Outcome Measures
Name Time Method Para-cellular permeability at time=0 Digestive discomfort degree at time=0 Inflammation molecule expression at time=0 Gap junction protein expression at time=0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of gastroenterology, Hopital Archet 2
🇫🇷Nice, France