Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Estimation of total tumor load and diagnosis of high-risk neurofibromas
研究概览
简要总结
Whole body MRI will be performed in patients with neurofibromatosis Type 1
PURPOSE 1:
To determine the total tumor load (neurofibroma) and to diagnose plexiform neurofibromas or malignant peripheral nerve sheath tumors. All patients will be scanned two years after the baseline whole body MRI to investigate to investigate the changes of total tumor load.
PURPOSE 2: added value of diffusion weighted imaging in diagnosis of high-risk neurofibromas
PURPOSE 3 : to determine the apparent diffusion coefficient of the malignant nerve sheath tumors and neurofibroma.
PURPOSE 4 : correlation between histopathology of the surgically resected neurofibroma/malignant nerve sheath tumors and MRI findings
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with neurofibromatosis type 1, between 6 and 50 years old
排除标准
- •Patients who are not allowed to be scanned on MRI (contra-indications: pacemaker ed.)
结局指标
主要结局
Estimation of total tumor load and diagnosis of high-risk neurofibromas
时间窗: 1 month
Estimation of the total tumor load of neurofibromas with whole body MRI (head to knee). Diagnosis of high risk neurofibroma in the chest, abdomen, pelvis, and extremities with T2-weighted sequence and diffusion weighted sequence.
次要结局
- To diagnose high-risk neurofibroma(2 months)
研究者
Steven Pans
Medical Doctor Radiologist
Universitaire Ziekenhuizen KU Leuven