Early Waning of Maternal Measles and Meningitis C Antibodies

• Conditions: Measles

• Registration Number: NCT02219061
• Lead Sponsor: Guangzhou Center for Disease Control and Prevention

Brief Summary

Maternal antibodies (measles and meningitis C) may wane in the first six months after birth.

* Geometric mean titers(GMTs) of measles and meningitis C.

* Follow-up on 0 month, 3rd month,5th month and 7th month after birth.

Detailed Description

Measles and meningitis C are hot topics in China in recent years. Although China had set the goal of measles elimination, many measles cases were found to be those aged \< 8 months and meningitis C is becoming public health issue since meningitis group A has been controlled at a very low level and little is known on C group. So the investigators designed the observation study on the two antibodies.

Maternal antibodies are supposed to wane after birth. Serums of the placenta(0 month), children of 3 months, 5 months and 7 months old will be collected and the geometric mean titers (GMTs) of measles and meningitis C will be confirmed by using the ELISA test.

Study Timeline

• Study Start: 2014-05
• Status Verified: 2014-08
• Study First Submitted: 2014-08-13
• Study First Submitted QC: 2014-08-14
• Study First Posted: 2014-08-18
• Last Update Submitted: 2014-09-16
• Last Update Posted: 2014-09-18
• Primary Completion: 2014-10
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Healthy infants.

Exclusion Criteria

• Infants with poor score.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Geometric Mean Titer	Up to six months

Trial Locations

Locations (1)

Guangzhou Center for Disease Control and Prevention; 🇨🇳 Guangzhou, Guangdong, China