Investigation of cognitive reserve and epigenetic modifications in individuals with a probable neurodegenerative disease
- Conditions
- G31.9Degenerative disease of nervous system, unspecified
- Registration Number
- DRKS00012575
- Lead Sponsor
- Klinik und Poliklinik für Nuklearmedizin, Uniklinik Köln
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Consent can be given, Suspected diagnosis of a neurodegenerative disease
Exclusion Criteria
Contraindiciations for PET imaging
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Individual proxies of the cognitive reserve will once be determined by means of different questionnaires (Lifetime Experience Questionnaire, MeDI Questionnaire, Questionnaire regarding schooling, social environment, RS-13 Resilience Questionnaire, Historical Leisure Activity Questionnaire) on the day of the routine PET examination. In addition, on the day of the routine PET examination, two peripheral blood samples will be taken, which will be assess for epigenetic changes. The acquired cognitive reserve measures and the epigenetic information will then be linked to the PET imaging parameters.
- Secondary Outcome Measures
Name Time Method