Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID
- Conditions
- COVID-19
- Registration Number
- NCT06427512
- Lead Sponsor
- Columbia University
- Brief Summary
AIM 1. Characterize cardiovascular phenotypes of long COVID by cardiopulmonary, meta-bolic, and cardiac mechanical/physiological responses to exercise and microvascular vasomotor function.
AIM 2. Identify intercellular signaling between immune cells and cardiac cells associated with microvascular phenotypes of long COVID.
- Detailed Description
As many as 40-60% of patients who recovered from mild or moderate acute COVID have reported what is now called long COVID - multiple, persistent or recurrent symptoms lasting 6-9 months (or longer) following initial illness.1-4 Fatigue, dyspnea, and chest pain are the most common symptoms. Others include palpitations, lightheadedness, and syncope. All these cardiovascular symptoms can be debilitating, resulting in worse quality of life and morbidity.5, 6 Treatment options are limited.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Age > 18, < 75 yrs
- History of lab-confirmed COVID
- Symptomatic at >12 wks post-acute COVID (cases)
- Recovered by 8wks post-acute COVID (controls)
- Any history of critical illness
- Chronic kidney disease, Stage >4
- Pre-COVID: HFrEF, CABG, arrhythmia; pulmonary hypertension, pulmonary embolus, interstitial lung disease (ILD), O2 dependence; dementia, stroke, autonomic dysfunction; coagulopathy
- Post-COVID: ILD, O2 dependence
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of Microvascular dysfunction Up to 2.5 years This is to measure the microvascular dysfunction in patients using Cardiac PET.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CUIMC
🇺🇸New York, New York, United States