Truth or Dare; Artificial Blastocoel Collapse Using Laser Before Blastocyst's Vitrification Versus Non-laser Usage

Not Applicable

Terminated

• Conditions: Blastocyst Disintegration
• Interventions: Device: laser assisted collapse

• Registration Number: NCT04124809
• Lead Sponsor: Benha University

Brief Summary

: This prospective randomized observational study aimed to compare behavior of artificially collapsed blastocysts to blastocysts that were vitrified without artificial collapse.

Detailed Description

One arm study of 60 patients with sibling blastocysts divided into 2 groups: Study group (artificially laser-collapsed blastocysts; n=71) \& control group (blastocysts were vitrified without laser collapse; n=66) then reexpansion speed and survival rate was assessed immediately \& at 140 min after thawing and compared between two groups.

Study Timeline

• Study Start: 2019-01-05
• Study First Submitted: 2019-10-08
• Study First Submitted QC: 2019-10-10
• Study First Posted: 2019-10-11
• Primary Completion: 2021-09-15
• Study Completion: 2021-10-01
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-18
• Last Update Posted: 2022-09-21

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

• Age limit 20-37 At least 6 good quality blastocysts per case. expansion rate 3-4

Exclusion Criteria

• bad quality blastocysts expansion rate less than 3

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Study group (artificially laser-collapsed blastocysts)	laser assisted collapse	laser was used as an intervention before blastocyst vitrification to assist rapid blastocyst collapse with vitrification

Primary Outcome Measures

Name	Time	Method
survival rate	140 min after thawing	survival rate will be assessed at 140 minutes after thawing and compared between both groups.

Trial Locations

Locations (1)

Hawaa Fertility Center; 🇪🇬 Banhā, Qalyubiya, Egypt