NCT07484126尚未招募不适用
A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation
Southeast University, China0 个研究点目标入组 2,000 人开始时间: 2026年4月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 2,000
- 主要终点
- ICU mortality
研究概览
简要总结
This study used a retrospective cohort study based on Multi-time longitudinal monitoring data were used to analyze the correlation mechanism between the dynamic evolution characteristics of nutrition-related biochemical indicators and individualized nutritional intervention in patients with mechanical ventilation. The inflammation-nutrition interaction model was constructed to correct the interference effect of inflammatory microenvironment on nutritional status assessment, so as to provide a basis for further achieving precision nutritional support.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 years old;
- •ICU admission ≥72 hours with invasive mechanical ventilation ≥24 hours;
- •start nutrition therapy within 72 hours after ICU admission and receive enteral or parenteral nutrition support for ≥3 days;
- •Relatively complete nutritional intervention records and nutrition-related biomarkers test results on the 1st, 3rd, and 7th (±1) days of ICU admission;
排除标准
- •women of childbearing age who have a positive pregnancy test, are pregnant or lactating;
- •chronic diseases with serious organ function damage or serious complications;
- •Kidney: chronic kidney disease stage 4 or 5;
- •Liver: previous history of liver failure, hepatic encephalopathy, or hepatic coma, gastrointestinal bleeding due to portal hypertension or Child-Pugh score ≥10 in recent years;
- •advanced malignant tumor, or chemotherapy or immunotherapy received within one month before admission;
- •severe immunodeficiency or current use of potent immunosuppressive agents, agranulocytosis (N<0.5×10^9/L), active hematologic malignancies or HIV stage III infection; Patients who were treated with immune-inducing drugs, such as antithymocyte globulin (ATG), antilymphocyte globulin (ALG), interleukin-2 receptor a chain antibody (IL-2RA), interleukin-6 receptor A antibody (IL-6RA); glucocorticoid therapy was continued for nearly 2 weeks, with a daily dose exceeding the hydrocortisone equivalent of 200mg;
- •critical illness, death in ICU within 1 week or palliative care only because death outcome was inevitable;
- •combined with severe or more severe burns: more than 30% of total body surface area burned or more than 10% of third-degree burn area; Or the total area is less than 30%, but the whole body condition is severe, or there are shock, combined injury, and respiratory tract burn.
研究组 & 干预措施
Patients in the ICU received mechanical ventilation
结局指标
主要结局
ICU mortality
时间窗: up to 24 months
次要结局
- Length of hospital Stay(up to 24 months)
- Incidence of hospital- acquired infections(up to 24 months)
- Hospital mortality(up to 24 months)
- Length of mechanical ventilation(up to 24 months)
- Length of ICU stay(up to 24 months)
- Incidence of gastrointestinal intolerance(up to 24 months)
研究者
Ling Liu
Professor
Southeast University, China
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