Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response
- Registration Number
- NCT06262932
- Lead Sponsor
- Police General Hospital, Thailand
- Brief Summary
The goal of this clinical trial is to compare in atrial fibrillation patient with rapid ventricular response. The main question it aims to answer are Effectiveness of Repeated Amiodarone dosing regimen versus standard dosing regimen in Atrial fibrillation patient with rapid ventricular response Participants will receive Amiodarone iv treatment with different regimen
* Repeated dosing regimen
* Standard dosing regimen
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 32
- Age above 18 years old
- Atrial fibrillation with rapid ventricular response patient (ventricular rate > 110)
- Baseline EKG Corrected QT interval (QTc) < 500 msec
- History of pulmonary fibrosis
- History of Cirrhosis
- Cardiac Index <2.2 L/min/m2 or Cardiogenic shock
- Unstable arrhythmia
- Receive amiodarone within 3 months prior to present illness
- Pregnancy
- Amiodarone or Iodine allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Repeated amiodarone bolus dosing regimen Amiodarone An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period. If the heart rate is still over 110 minutes after the initial treatment, provide an additional 150 mg IV amiodarone bolus over a 15-minute period. During the first 24 hours, this bolus may be administered up to three times in total. Within 24 hours of finishing the first bolus dosage, 900 mg of amiodarone will be administered intravenously. Standard dosing regimen Amiodarone An Initial 150 mg IV amiodarone bolus should be given over a 15-minute period, then a 24-hour amiodarone loading infusion 900 mg over 24 hours
- Primary Outcome Measures
Name Time Method Heart rate 6-hours after receiving amiodarone bolus Percentage of patients who have Atrial fibrillation with rapid ventricular response, the percentage of patients who have heart rate below 110 bpms at 6 hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have heart rate below 110 bpms at 6 hour after a conventional amiodarone IV loading dose regimen
- Secondary Outcome Measures
Name Time Method Heart rate 24-hours after receiving amiodarone bolus Percentage of patients who have Atrial fibrillation with rapid ventricular response, the percentage of patients who have heart rate below 110 bpms at 24 hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have heart rate below 110 bpms at 6 hour after a conventional amiodarone IV loading dose regimen
Major adverse cardiovascular events 30 days after receiving amiodarone bolus Number of MACE \[MACE defined as acute myocardial infarction (AMI), stroke, or cardiovascular death\]
Phlebitis 24-hours after receiving amiodarone bolus Rate of phlebitis complication during amiodarone infusion
Normal sinus rhythm at 24 hours 24-hours after receiving amiodarone bolus Percentage of patients who develop Atrial fibrillation with rapid ventricular response, the percentage of patients who have converted to sinus rhythm at 24-hours after receiving a repeated amiodarone bolus and loading dose regimen to the percentage of patients who have converted to sinus rhythm after a conventional amiodarone IV loading dose regimen
Changed in heart rate 24-hours after receiving amiodarone bolus Compare number of total heart rate induction in patients who received a repeated amiodarone bolus and loading dose regimen and a conventional amiodarone IV loading dose regimen at 24 hrs