Defining the optimal dose for continuous flucloxacillin infusio
- Conditions
- infectionskineticsinfusionflucloxacillin
- Registration Number
- NL-OMON28330
- Lead Sponsor
- Deventer Hospital
- Brief Summary
none
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
The patient is at least 18 years of age
-The patient has started with intravenous flucloxacillin as indicated by their physician
Exclusion Criteria
The patient who is admitted to the intensive care unit
-Pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Part A: (step 1) A quantitative description of the pharmacokinetics flucloxacillin in non-critically ill patients: changes in (unbound) flucloxacillin level-time profiles and the possible relationship with renal function and demographics. Step 2: A dosing regime for continuous administration of flucloxacillin in which 90% of the population exceeds 100% fT>MIC. Part B: The percentage of patients exceeding the PK target of 100% fT>MIC with the new dosing regime.
- Secondary Outcome Measures
Name Time Method Part B: A description of the tolerability of the new continuous dosing scheme.