Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma
- Conditions
- Osteosarcoma
- Interventions
- Other: Cytology Specimen Collection Procedure
- Registration Number
- NCT00899275
- Lead Sponsor
- Children's Oncology Group
- Brief Summary
The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.
- Detailed Description
OBJECTIVES:
I. To collect biological specimens from patients with osteosarcoma at Children?s Oncology Group (COG) institutions.
II. To provide a repository for long-term storage of osteosarcoma-related biological materials.
III. To make these specimens available to qualified researchers to understand the biology of osteosarcoma and correlate these results with the patients' clinical data.
OUTLINE:
After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 957
-
All osteosarcoma patients seen at COG institutions are eligible, including the following:
- Newly diagnosed patients
- Patients with recurrent disease who were not enrolled at the time of diagnosis
-
The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:
- Paraffin embedded block OR 30 unstained slides
- Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
- Fresh and frozen tumor specimens
-
Patients are not required to enter a therapeutic study to enroll on this study
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Ancillary-correlative Cytology Specimen Collection Procedure After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.
- Primary Outcome Measures
Name Time Method Collection of biological specimens from patients with osteosarcoma Baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (180)
Driscoll Children's Hospital
🇺🇸Corpus Christi, Texas, United States
Marshfield Medical Center-Marshfield
🇺🇸Marshfield, Wisconsin, United States
West Virginia University Charleston Division
🇺🇸Charleston, West Virginia, United States
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Royal Children's Hospital-Brisbane
🇦🇺Herston, Queensland, Australia
Children's Hospital Los Angeles
🇺🇸Los Angeles, California, United States
Mattel Children's Hospital UCLA
🇺🇸Los Angeles, California, United States
UCLA / Jonsson Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Children's Healthcare of Atlanta - Egleston
🇺🇸Atlanta, Georgia, United States
Nationwide Children's Hospital
🇺🇸Columbus, Ohio, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
🇺🇸Baltimore, Maryland, United States
Saint Christopher's Hospital for Children
🇺🇸Philadelphia, Pennsylvania, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Children's Hospital of Pittsburgh of UPMC
🇺🇸Pittsburgh, Pennsylvania, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
University of Illinois
🇺🇸Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
🇺🇸Chicago, Illinois, United States
Seattle Children's Hospital
🇺🇸Seattle, Washington, United States
Floating Hospital for Children at Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Miami Cancer Institute
🇺🇸Miami, Florida, United States
Riley Hospital for Children
🇺🇸Indianapolis, Indiana, United States
Saint Vincent Hospital and Health Care Center
🇺🇸Indianapolis, Indiana, United States
University Medical Center of Southern Nevada
🇺🇸Las Vegas, Nevada, United States
Nevada Cancer Research Foundation CCOP
🇺🇸Las Vegas, Nevada, United States
Sunrise Hospital and Medical Center
🇺🇸Las Vegas, Nevada, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
🇺🇸Las Vegas, Nevada, United States
Summerlin Hospital Medical Center
🇺🇸Las Vegas, Nevada, United States
Rady Children's Hospital - San Diego
🇺🇸San Diego, California, United States
University of Minnesota/Masonic Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Methodist Children's Hospital of South Texas
🇺🇸San Antonio, Texas, United States
University of Texas Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
UCSF Medical Center-Parnassus
🇺🇸San Francisco, California, United States
UCSF Medical Center-Mission Bay
🇺🇸San Francisco, California, United States
Vanderbilt University/Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Primary Children's Hospital
🇺🇸Salt Lake City, Utah, United States
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
Valley Children's Hospital
🇺🇸Madera, California, United States
Lurie Children's Hospital-Chicago
🇺🇸Chicago, Illinois, United States
Lucile Packard Children's Hospital Stanford University
🇺🇸Palo Alto, California, United States
City of Hope Comprehensive Cancer Center
🇺🇸Duarte, California, United States
Children's Hospital and Research Center at Oakland
🇺🇸Oakland, California, United States
Golisano Children's Hospital of Southwest Florida
🇺🇸Fort Myers, Florida, United States
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Kaiser Permanente-Oakland
🇺🇸Oakland, California, United States
Miller Children's and Women's Hospital Long Beach
🇺🇸Long Beach, California, United States
Broward Health Medical Center
🇺🇸Fort Lauderdale, Florida, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
🇺🇸Hollywood, Florida, United States
Southern Illinois University School of Medicine
🇺🇸Springfield, Illinois, United States
Alfred I duPont Hospital for Children
🇺🇸Wilmington, Delaware, United States
Nemours Children's Clinic - Pensacola
🇺🇸Pensacola, Florida, United States
Lee Memorial Health System
🇺🇸Fort Myers, Florida, United States
Johns Hopkins All Children's Hospital
🇺🇸Saint Petersburg, Florida, United States
Connecticut Children's Medical Center
🇺🇸Hartford, Connecticut, United States
Arkansas Children's Hospital
🇺🇸Little Rock, Arkansas, United States
Children's Hospital of Orange County
🇺🇸Orange, California, United States
Kaiser Permanente Downey Medical Center
🇺🇸Downey, California, United States
Children's National Medical Center
🇺🇸Washington, District of Columbia, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
🇺🇸New York, New York, United States
Rainbow Babies and Childrens Hospital
🇺🇸Cleveland, Ohio, United States
University of Iowa/Holden Comprehensive Cancer Center
🇺🇸Iowa City, Iowa, United States
Saint Mary's Hospital
🇺🇸West Palm Beach, Florida, United States
Columbia Regional
🇺🇸Columbia, Missouri, United States
Memorial Health University Medical Center
🇺🇸Savannah, Georgia, United States
Saint Luke's Mountain States Tumor Institute
🇺🇸Boise, Idaho, United States
Naval Medical Center -San Diego
🇺🇸San Diego, California, United States
Helen DeVos Children's Hospital at Spectrum Health
🇺🇸Grand Rapids, Michigan, United States
Overlook Hospital
🇺🇸Summit, New Jersey, United States
Eastern Maine Medical Center
🇺🇸Bangor, Maine, United States
New York Medical College
🇺🇸Valhalla, New York, United States
Kalamazoo Center for Medical Studies
🇺🇸Kalamazoo, Michigan, United States
Mission Hospital Inc-Memorial Campus
🇺🇸Asheville, North Carolina, United States
Novant Health Presbyterian Medical Center
🇺🇸Charlotte, North Carolina, United States
Nemours Children's Clinic-Jacksonville
🇺🇸Jacksonville, Florida, United States
University of Kansas Cancer Center
🇺🇸Kansas City, Kansas, United States
Morristown Medical Center
🇺🇸Morristown, New Jersey, United States
Saint Joseph's Regional Medical Center
🇺🇸Paterson, New Jersey, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Cardinal Glennon Children's Medical Center
🇺🇸Saint Louis, Missouri, United States
Advocate Children's Hospital-Oak Lawn
🇺🇸Oak Lawn, Illinois, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
🇺🇸New York, New York, United States
UT Southwestern/Simmons Cancer Center-Dallas
🇺🇸Dallas, Texas, United States
Brooke Army Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
East Tennessee Childrens Hospital
🇺🇸Knoxville, Tennessee, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Stony Brook University Medical Center
🇺🇸Stony Brook, New York, United States
Bronson Methodist Hospital
🇺🇸Kalamazoo, Michigan, United States
State University of New York Upstate Medical University
🇺🇸Syracuse, New York, United States
Carolinas Medical Center/Levine Cancer Institute
🇺🇸Charlotte, North Carolina, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Saint Jude Midwest Affiliate
🇺🇸Peoria, Illinois, United States
BI-LO Charities Children's Cancer Center
🇺🇸Greenville, South Carolina, United States
Michigan State University Clinical Center
🇺🇸East Lansing, Michigan, United States
The Steven and Alexandra Cohen Children's Medical Center of New York
🇺🇸New Hyde Park, New York, United States
Scott and White Memorial Hospital
🇺🇸Temple, Texas, United States
Medical City Dallas Hospital
🇺🇸Dallas, Texas, United States
Dayton Children's Hospital
🇺🇸Dayton, Ohio, United States
Alberta Children's Hospital
🇨🇦Calgary, Alberta, Canada
Mount Sinai Hospital
🇺🇸New York, New York, United States
Cook Children's Medical Center
🇺🇸Fort Worth, Texas, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Penn State Children's Hospital
🇺🇸Hershey, Pennsylvania, United States
Children's Hospital Medical Center of Akron
🇺🇸Akron, Ohio, United States
Madigan Army Medical Center
🇺🇸Tacoma, Washington, United States
Sanford USD Medical Center - Sioux Falls
🇺🇸Sioux Falls, South Dakota, United States
Inova Fairfax Hospital
🇺🇸Falls Church, Virginia, United States
Princess Margaret Hospital for Children
🇦🇺Perth, Western Australia, Australia
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
🇺🇸New Brunswick, New Jersey, United States
University of Rochester
🇺🇸Rochester, New York, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Brooklyn Hospital Center
🇺🇸Brooklyn, New York, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Newark Beth Israel Medical Center
🇺🇸Newark, New Jersey, United States
Childrens Oncology Group
🇺🇸Philadelphia, Pennsylvania, United States
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Kingston Health Sciences Centre
🇨🇦Kingston, Ontario, Canada
Hospital for Sick Children
🇨🇦Toronto, Ontario, Canada
Sanford Broadway Medical Center
🇺🇸Fargo, North Dakota, United States
Children's Hospital of Eastern Ontario
🇨🇦Ottawa, Ontario, Canada
IWK Health Centre
🇨🇦Halifax, Nova Scotia, Canada
University of Vermont and State Agricultural College
🇺🇸Burlington, Vermont, United States
Women's and Children's Hospital-Adelaide
🇦🇺North Adelaide, South Australia, Australia
Prisma Health Richland Hospital
🇺🇸Columbia, South Carolina, United States
Carilion Clinic Children's Hospital
🇺🇸Roanoke, Virginia, United States
Queensland Children's Hospital
🇦🇺South Brisbane, Queensland, Australia
T C Thompson Children's Hospital
🇺🇸Chattanooga, Tennessee, United States
Greenville Cancer Treatment Center
🇺🇸Greenville, South Carolina, United States
West Virginia University Healthcare
🇺🇸Morgantown, West Virginia, United States
British Columbia Children's Hospital
🇨🇦Vancouver, British Columbia, Canada
Providence Sacred Heart Medical Center and Children's Hospital
🇺🇸Spokane, Washington, United States
Centre Hospitalier Universitaire Sainte-Justine
🇨🇦Montreal, Quebec, Canada
San Jorge Children's Hospital
🇵🇷San Juan, Puerto Rico
Children's Hospital of The King's Daughters
🇺🇸Norfolk, Virginia, United States
The Montreal Children's Hospital of the MUHC
🇨🇦Montreal, Quebec, Canada
Starship Children's Hospital
🇳🇿Grafton, Auckland, New Zealand
McMaster Children's Hospital at Hamilton Health Sciences
🇨🇦Hamilton, Ontario, Canada
CancerCare Manitoba
🇨🇦Winnipeg, Manitoba, Canada
Phoenix Childrens Hospital
🇺🇸Phoenix, Arizona, United States
Ascension Saint John Hospital
🇺🇸Detroit, Michigan, United States
Wayne State University/Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
University of Alabama at Birmingham Cancer Center
🇺🇸Birmingham, Alabama, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
🇺🇸Denver, Colorado, United States
Legacy Emanuel Children's Hospital
🇺🇸Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center
🇺🇸Portland, Oregon, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Children's Hospital and Medical Center of Omaha
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Children's Hospital of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Children's Hospital Colorado
🇺🇸Aurora, Colorado, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
🇺🇸Tampa, Florida, United States
Children's Hospital of Alabama
🇺🇸Birmingham, Alabama, United States
C S Mott Children's Hospital
🇺🇸Ann Arbor, Michigan, United States
Wake Forest University Health Sciences
🇺🇸Winston-Salem, North Carolina, United States
Dell Children's Medical Center of Central Texas
🇺🇸Austin, Texas, United States
Yale University
🇺🇸New Haven, Connecticut, United States
AdventHealth Orlando
🇺🇸Orlando, Florida, United States
Arnold Palmer Hospital for Children
🇺🇸Orlando, Florida, United States
Nemours Children's Clinic - Orlando
🇺🇸Orlando, Florida, United States
UF Cancer Center at Orlando Health
🇺🇸Orlando, Florida, United States
Nemours Children's Hospital
🇺🇸Orlando, Florida, United States
Norton Children's Hospital
🇺🇸Louisville, Kentucky, United States
Children's Mercy Hospitals and Clinics
🇺🇸Kansas City, Missouri, United States
UNC Lineberger Comprehensive Cancer Center
🇺🇸Chapel Hill, North Carolina, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
🇺🇸New Orleans, Louisiana, United States
University of Hawaii Cancer Center
🇺🇸Honolulu, Hawaii, United States
Kapiolani Medical Center for Women and Children
🇺🇸Honolulu, Hawaii, United States
Montefiore Medical Center - Moses Campus
🇺🇸Bronx, New York, United States
University of Kentucky/Markey Cancer Center
🇺🇸Lexington, Kentucky, United States
University of New Mexico Cancer Center
🇺🇸Albuquerque, New Mexico, United States
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada