NCT06205784已完成不适用
Prehabilitative Exercise - Can the Physiological Consequences of Immobilization be Prevented?
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Quadriceps cross-sectional area
研究概览
简要总结
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance exercise training (HReT). Half of the participants (12 younger and 12 older) will also undergo 4 weeks HReT prior to the immobilization. Prehabilitative exercise may confer protective effects on subsequent immobilization, and the various underlying mechanisms involved
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: Between 20-35 years old or between 65-85 years old.
- •BMI: Between 18.5 and 35 kg/m
- •Healthy and well, with normal dietary habits (not vegan).
排除标准
- •More than one muscle biopsy previously taken from both vastus lateralis muscles.
- •Pregnancy.
- •Past or present substance or alcohol abuse.
- •Medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial.
- •Knee pain that could affect the completion of the training intervention.
- •High intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger).
- •Participation in regular strength training within the past year.
- •Regular participation in structured sports.
- •Current use of blood-thinning medication.
- •Previous participation in trials involving oral intake of heavy water.
- •Metal in the body preventing MRI scanning.
- •For the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.
研究组 & 干预措施
Prehab
Experimental
干预措施: Prehabilitative exercise (Other)
NoTrain
No Intervention
结局指标
主要结局
Quadriceps cross-sectional area
时间窗: From pre (week 0) to post immobilization (week 5)
Quadriceps cross-sectional area measured by MRI
次要结局
- Brain structure(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Tendon ultrastructure(From pre immobilization (week 4) to post immobilization (week 5))
- Muscle protein synthesis(From pre immobilization (week 4) to post immobilization (week 5))
- Tendon structure(From pre (week 0) to post immobilization (week 5))
- Balance(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Force variability(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Brain function(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Lean-body mass(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Muscle strength(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Muscle fiber size(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Denervated muscle fibers(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
- Muscle gene expression(From pre (week 0) to post immobilization (week 5) and post retraining (week 10))
研究者
Casper Soendenbroe
Postdoc
Bispebjerg Hospital
研究点 (1)
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