Tooth replacement by Implants & Blood Platelets substitutes

Phase 3

Not yet recruiting

Conditions: Partial loss of teeth,

Registration Number: CTRI/2023/08/056520

Lead Sponsor: Dr Komali Kasukurthi

Brief Summary: | |

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|NEED FOR THE STUDY:

Successful osseointegration is the first step in long-term survival and stability of a dental implant. Surface modifications by implant manufacturers are aimed at improving the bone-implant contact and another technique for improving the bone-implant contact and reducing osseointegration time could be represented by the use of autologous blood derivatives that contain a rich supply of growth factors and bone-specific proteins*.*1

Injectable platelet-rich fibrin (i-PRF) is the most recent and successful advancement in PRF and is beneficial for bone augmentation of the alveolar ridge prior to or during implant placement and wound healing.2

Use of i-PRF as a surface coating performed as a chairside procedure to coat the surface of the implant just prior to placement can be implemented to improve osseointegration. It could possibly serve as a simple, economical, and effective way of ensuring better implants success and quicker treatment time. As it is in a liquid formulation, it can be evenly applied all over the implant surface.1

The scientific data regarding the i-prf coated implants is inadequate. Hence, the present study is designed to evaluate and compare implants with and without i-PRF coating.

**SURFACE COATING OF IMPLANT WITH i-PRF:**

Ã˜ The osteotomy sites will be prepared using standard sequential drilling protocol for the full sequence.

Ã˜ Just before implant placement the i-PRF will be prepared.

Ã˜ For i-PRF preparation,10 ml of whole blood without anticoagulant will be centrifuged at 700 rpm for 3 min at room temperature. 3

Ã˜ After 3 mins the straw-colored liquid present at the top which is i-PRF will be collected.

Ã˜ 1.5 ml of i-PRF liquid will be used to coat the implants by dipping in i-PRF.

**RESEARCH QUESTION** - Does implant with i-PRF will have better implant stability and crestal bone levels when compared to implants without i-PRF?

**RESEARCH HYPOTHESIS [H1]** - Implant with i-PRF may have better implant stability and crestal bone levels when compared to implants without i-PRF.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

1.Patients of age group 20.
60 years. 2.Patients with single edentulous sites in either jaw. 3.Absence of restoration/prosthesis adjacent to edentulous site. 4.Healed extraction socket site â‰¥ 3 months.

Exclusion Criteria

1.Patients with systemic diseases.
3.Pregnant or lactating women.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Implant Stability And Crestal Bone Levels	Base line & \| 3 MONTHS

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Kamineni Institute of Dental Sciences
🇮🇳
Nalgonda, TELANGANA, India
Kamineni Institute of Dental Sciences
🇮🇳Nalgonda, TELANGANA, India
Dr Komali Kasukurthi
Principal investigator
9491511968
komalikasukurthi19@gmail.com