CT-based Radiomic Signature Can Identify Adenocarcinoma Lung Tumor Histology

• Conditions: Nonsmall Cell Lung Cancer
• Interventions: Diagnostic Test: Virtual biopsy

• Registration Number: NCT03940846
• Lead Sponsor: Maastricht University

Brief Summary

Lung cancer remains the leading cause of cancer related mortality worldwide, with more than 1.5 million related deaths annually. Lung cancer is divided into two main groups: Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC), with prevalence of \~20% and 80% respectively. NSCLC is further subdivided into adenocarcinoma (the most common), squamous cell carcinoma (SCC), and large cell carcinoma. Furthermore, each subtype is likely to have specific mutations, which could be targeted for treatment.

Medical imaging and radiomics feature extraction represent a candidate alternative to conventional tissue biopsy, a theory that is investigated in this study.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-01
• Status Verified: 2019-04
• Study First Submitted: 2019-05-06
• Study First Submitted QC: 2019-05-06
• Study First Posted: 2019-05-07
• Last Update Submitted: 2020-04-03
• Last Update Posted: 2020-04-06
• Primary Completion: 2020-10-31
• Study Completion: 2021-01-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 650

Inclusion Criteria

• Availability of diagnostic non-contrast enhanced CT scan.
• Availability of histologic tumor analysis results

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Stanford	Virtual biopsy	Open source dataset available at TCIA.org. The cohort includes CT scans of 211 patients diagnosed with NSCLC.
Radboud	Virtual biopsy	A cohort of patients diagnosed with NSCLC at Radboud medical center. It includes CT scans of 255 patients.
UCSF	Virtual biopsy	A cohort of patients diagnosed with NSCLC at UCSF medical center. It includes CT scans of 165 patients.
Maastro (Lung1)	Virtual biopsy	Open source dataset available at TCIA.org. The cohort includes CT scans of 422 patients diagnosed with NSCLC.

Primary Outcome Measures

Name	Time	Method
Lung histology	December 2019	Is the tumor under investigation an adenocarcinoma of the lung?

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Limburg, Netherlands