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Clinical Trials/NCT05831696
NCT05831696
Recruiting
Not Applicable

Metabolic Cost of Walking With Passive vs. Powered Prosthetic Knees Among Persons With Limb Loss

Loma Linda University1 site in 1 country12 target enrollmentFebruary 27, 2023

Overview

Phase
Not Applicable
Intervention
Powered Microprocessor-controlled Knee (PMPK)
Conditions
Transfemoral Amputation
Sponsor
Loma Linda University
Enrollment
12
Locations
1
Primary Endpoint
VO2 uptake - level ground
Status
Recruiting
Last Updated
2 months ago

Overview

Brief Summary

The purpose of this industry-initiated research study is to test that a powered microprocessor controlled knee improves metabolic function during walking in level and sloped conditions as compared to the subject's physician prescribed prosthesis.

Detailed Description

The Procedures include: Initial Visit: 1. Informed consent 2. HIPAA authorization 3. Determine/verify ambulation potential 4. Take and record body measurements (height, weight, circumferences) 5. Activities-Specific Balance Confidence (ABC) scale 6. L.A.S.A.R. Posture alignment assessment with RxPx Second Visit 1. Fit with heartrate monitor and metabolic analyzer mask 2. Treadmill Test (level-ground) with RxPx 3. Rest 4. Treadmill Test (incline) with RxPx 5. Fit subject with PMPK 6. L.A.S.A.R. Posture alignment assessment with PMPK 7. Subject uses PMPK for one week as their primary prosthesis Third Visit (1 week later) 1. Fit with heartrate monitor and metabolic analyzer mask 2. Treadmill Test (level-ground) with PMPK 3. Rest 4. Treadmill Test (incline) with PMPK 5. Activities-Specific Balance Confidence (ABC) scale 6. Return PMPK and refit of RxPx 7. Verify alignment with L.A.S.A.R. Posture alignment 8. Check that all fasteners are secure

Registry
clinicaltrials.gov
Start Date
February 27, 2023
End Date
December 1, 2026
Last Updated
2 months ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Males and Females with unilateral knee disarticulation or transfemoral (KD/TF) amputation.
  • a body mass greater than 49Kg and less than 117Kg
  • 18-75 years of age
  • Have an ambulation potential of K3 or K4
  • Use a prosthesis daily for walking or sports activities
  • No less than six months of experience with a prosthesis
  • No socket issues or changes in the last six weeks
  • No residual limb pain affecting functional ability.

Exclusion Criteria

  • Cannot walk at different speeds (MCFL K0-K2)
  • Limb-loss below the knee or through the hip
  • More than one amputation.
  • Uses an assistive device for walking
  • Uncontrolled edema in leg compartments
  • Compromised skin of the residual limb or contralateral foot
  • Are 180 days or less post-amputation
  • Pregnant (self-reported)

Arms & Interventions

Powered Microprocessor-controlled Knee (PMPK)

the "Power Knee" is a commercially available PMPK.

Intervention: Powered Microprocessor-controlled Knee (PMPK)

Outcomes

Primary Outcomes

VO2 uptake - level ground

Time Frame: Change between Baseline Visit (study enrollment) and Visit 2 (3 weeks post-study enrollment)

VO2 uptake during ambulation on a treadmill - level ground

VO2 uptake - incline

Time Frame: Visit 2 (3 weeks post-study enrollment)

VO2 uptake during ambulation on a treadmill - 5 degree incline

Secondary Outcomes

  • Balance confidence(At Baseline Visit (study enrollment))
  • Exertion(Change between Visit 2 (3 weeks post-study enrollment) and Visit 3 (4 weeks post-study enrollment))

Study Sites (1)

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