Determining various molecular/genetic changes associated with > 10mm depth of invasion in head and neck malignancies
概览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- DY Patil University
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To find various genetic mutation or molecular changes found in head and neck cancer cells having depth of invasion more than 10 mm
概览
简要总结
Patients will be divided into those having depth of invasion less than 10 mm and equal to or more than 10 mm as per final histopathology report post surgical excision. Genetic/ molecular changes in these patients will be compared and analyzed. patients will be followed prospectively till 2 years and clinicopatholgoical correlation with tumor genetics will be done.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients of oral cancers undergoing surgery in our department.
排除标准
- •Palliative resection and metastatic patients.
结局指标
主要结局
To find various genetic mutation or molecular changes found in head and neck cancer cells having depth of invasion more than 10 mm
时间窗: Patient will be accessed, at presentation, after completion of treatment, at 3 months, at 6 months, at 12 months and at 2nd year. | All follow ups will be as per standard protocol for disease follow up and no extra follow for study will be done unless indicated clinically. | Genetic analysis will be done on tumor tissue blocks once histopathology report of tumor is available.
次要结局
- To find any targetable molecular change associated with head and neck cancers having depth of invasion more than 10 mm(At the end of 2 years)
研究者
Dr Samir Gupta
DY Patil Medical College