Prophylactic antibiotics for the prevention of meningitis after traumatic pneumocephalus
Not Applicable
Completed
- Conditions
- Traumatic pneumocephalus (entrance of air into the cranium after head trauma)Injury, Occupational Diseases, PoisoningTraumatic pneumocephalus
- Registration Number
- ISRCTN71132784
- Lead Sponsor
- Tehran University of Medical Sciences (TUMS) (Iran)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 186
Inclusion Criteria
1. Traumatic pneumocephalus verified by brain computed tomography (CT) scan
2. The patients should be hospitalised less than 24 hours after trauma
Exclusion Criteria
1. Patients who have received antibiotic therapy for other reasons
2. Individuals with penetrating traumatic brain injury, open skull fractures or operated for any causes
3. Those who are discharged from hospital with personal consent
4. All cases with life threatening lesions including severe brain, abdominal or vascular injuries and death due to other causes
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The frequency of bacterial meningitis in IV, O and P groups.
- Secondary Outcome Measures
Name Time Method 1. The frequency of rhinorrhoea, intracranial haemorrhage and skull base fracture, volume and location of intracranial air in the population study and each of the IV, O and P groups.<br>2. The mortality rate in study population and each of the IV, O and P groups