Diabetes mellitus and its management with unani medicine

Not yet recruiting

• Conditions: Type 2 diabetes mellitus without complications, (2) ICD-10 Condition: E119||Type 2 diabetes mellitus without complications,

• Registration Number: CTRI/2022/10/046705
• Lead Sponsor: PG DEPARTMENT OF MOALEJAT GENERAL MEDICINE GOVT.NIZAMIA TIBBI COLLEGE AND GENERAL HOSPITAL

Brief Summary

.Diabetes mellitus is a heterogeneous group condition with disordered metabolism& inappropriate hyperglycemia due to either a deficiency of insulinsecretion or to a combination of insulin resistance and inadequate insulinsecretion. Giving rise to microvascular  damage (Retinopathy, Nephropathy,Neuropathy).

.  The term Diabetes was first coined by Araetus Cappodocia.Later mellitis(honeysweet) addedbtThomas Willis.

.  ZIABETES is Greek word which means “ to runthrough †or siphon.

.  There are estimated 72.96 million cases of diabetes in adult population of India.(INDIAB Study)10-oct-2019.

**UNANI CONCEPT:**

Su-e-Mizaj Haar Gurda(Hot derangement in temperamentof kidney):

Økidneys absorbs water from circulationdue to excessive hotness or derangement in temperament. Therefore they can’tretain much amount of fluid & pass in the form of urine. (frequentlypolyuria) to overcome the thirst. (AL-QANOON)

Su-e-Mizaj Barid Gurda(cold derangement in temperamentof Kidney):

Ø sometimes excessive exposure of cold to kidneyleads to sue mizaj bariddevelops diabetes.



**MODERN CONCEPT:**

üAccording tomodern concept,diabetes mellitus is heterogenous metabolic disorder characterized   by hyperglycemia with disturbance ofcarbohydrate, fat and protein metabolism.

üInadequateinsulin secretion, increase glucose production, tissue resistance to insulin or combination of any of these.

üGenetic& environmental factors combine to cause both insulin resistance & betacell loss.

üIncidenceof T2DM is Rising  due to rising obesityand reduced activity levels.



ENTRY OF GLUCOSE INTO THE CELL:

.Glucose concentration in cell< Plasma (less than 100mg/dl)

.Doesn’t enter by simple diffusion

1.Insulinindependent transport system of glucose: Hepatocytes,RBC, Brain

2.Insulindependent transport  system of glucose :Muscle& adipose tissue

GLUT2

GLUT4

Deficency ofGLUT4 results  insulin resistance.

**SIGN AND SYMPTOMS:**

üSAL-A-SUL  BAUL (POLYURIA)

üATASH  MAFRAT (POLYDIPSIA)

üPOLYPHAGIA

üUNEXPLAINED  WEIGHT LOSS

üCHRONICSKIN INFECTION LIKE PRURITIS, VAGINITIS

**INVETIGATION:**

FBS

PLBS

HBA1C

C-PEPTIDE



**REFERENCES:**

üSHARAH-E-ASBAB BY ALLAMA NAJEEBUDDIN SAMARQANDI TRANSALTED BY HAKEEM ALLAMA MOHAMMED KABEERUDDIN Page; 29-35 üKITABUL HAWI FIT-TIB BY ZAKARIA RAZI VOL 10 Page:181-194 üKITAB AL-AKSEER BY ALLAMA HAKEEM MOHAMMED KABEERUDDIN VOL.2 Page:1195 üKAMILUS-SANAT BY ABUL HASAN ALI IBN ABBAS MAJOOSI URDU TRANSALATION BY HAKEEM GHULAM HUSSAIN  VOL.2 Page ; 469   üZAKHEERA-E-KHWARZAMSHAHI by AHMED ALHASAN AL-JARJANI Translation by Hakeem hadi HUSSAIN KHAN(IDARA KITABUSH SHIFA DARYA GANJ NEW DELHI) page no. 540,541 üALQANON FIT TIB by SHAIKH UR RAEES BU ALI IBN SINA (IDARA KITABUSH-SHIFA DARYA GANJ DELHI) Page:248,249,250 üHAAZIQby HAKEEM MOHAMMED AJMAL KHAN (IDARA KITABUSH SHIFA DELHI) Page 387 üHARISON’SVol.2 17th,edition page 2275,2278 üDAVIDSON’SEdition 20th Page:805 üMACLEODSCLINICAL EXAMINATION 12THEdition page:94,95 üCURRENTMEDICAL DIAGNOSISAND TREATMENT EDITION 2017Page:121

üINDIANMATERICA MEDIA (DR.KM NADKARNI’S) VOL.1 Page;596

AL-

**-**AKSEERHAKEEM MOHAMMED AZAM KHAN TRANSLATION BY HAKEEM MOHAMMED KABEERUDIN Page:818

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-10-19
• Study Start: 2022-10-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1.HBA1C 6.5gm% TO 7.5gm% 2.DIABETIC NEUROPATHY 3.FBS 120 TO 160mg/dl 4.PLBS 180 TO 300 mg/dl.

Exclusion Criteria

1.TYPE 1 DIABETES 2.PREGNANT AND LACTATING WOMEN 3.DIABETES WITH CARDIOVASCULAR DISEASE 4.DIABETES WITH RENAL DISORDER 5.MALIGNANCY 6.DIABETIC KETOACIDOSIS 7.SUBJECTS ON INSULIN THERAPY.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TO ACHIEVE THE BLOOD GLUCOSE LEVELS IN NORMAL RANGE.	EVERY 10 th DAY FOR 40 DAYS
i.e FBS - 70 TO 110.	EVERY 10 th DAY FOR 40 DAYS
PLBS- 120 TO 180	EVERY 10 th DAY FOR 40 DAYS

Secondary Outcome Measures

Name	Time	Method
DECREASE IN SYMPTOMS OF POLYDIPSIA, POLYPHAGIA, POYURIA	EVERY 10 th DAY FOR 40 DAYS

Trial Locations

Locations (1)

GOVT.NIZAMIA TIBBI COLLEGE AND GENERAL HOSPITAL; 🇮🇳 Hyderabad, TELANGANA, India

GOVT.NIZAMIA TIBBI COLLEGE AND GENERAL HOSPITAL

🇮🇳Hyderabad, TELANGANA, India

DR SHAIKH ATEEQUR RAHMAN

Principal investigator

9595426262

ateequrrahman65@gmail.com