SCFA Production and Their Metabolic Effects After Inulin Ingestion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Fat oxidation, energy expenditure
研究概览
简要总结
In this placebo controlled, double-blind, randomized crossover study the investigators will investigate in overweight/obese healthy male volunteers whether inulin administration will increase intestinal SCFA production, thereby investigating whether this will lead to acute metabolic effects.
详细描述
Gut microbiota is being increasingly recognized as an important factor in fat distribution, insulin sensitivity and glucose and lipid metabolism. Accordingly, the intestinal microbiota could play an important role in the development of obesity and type 2 diabetes mellitus. The role of gut-derived short-chain fatty acids (SCFA), the formation of which is enhanced by microbial fermentation of fibre, is still controversial. At the present time, our understanding of the effects of SCFA on human metabolism (in gut or systemically) is still limited. The investigators hypothesize that the ingested prebiotic inulin is fermented into SCFA and these SCFA have metabolic effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Overweight, obese men
排除标准
- •diabetes mellitus
结局指标
主要结局
Fat oxidation, energy expenditure
时间窗: 1 study day for each administration
Fat oxidation and energy expenditure are measured after inulin ingestion
次要结局
- Appetite VAS scoring(1 study day for each administration)
- Hormones that influence substrate and energy metabolism(1 study day for each administration)
- SCFAs(1 study day for each administration)
- Breath sampling 13CO2(1 study day for each administration)
- Circulating metabolites(1 study day for each administration)