spinal anaesthesia with , hyperbaric bupivacaine vesrsus ropivacaine

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/02/049861
• Lead Sponsor: Jitendra kalbande

Brief Summary

Both bupivacaine and ropivacaine is amide group of local anaesthetics ,but bupivacaine has more cardiotoxicity. Further ropivacaine has the advantage of the differential blockade. Therefore ropivacaine allows early ambulation, less DVT, and other advantages of ambulation.

On the other hand, as per minimal local anaesthetics concentration, ropivacaine has a comparable potency to bupivacaine at higher doses but lesser potency at lower dosages. As a result when administered in a ratio of 1.5:1 with bupivacaine, ropivacaine deliver comparable block quality with fewer side effects. Additionally, hyperbaric solutions are more predictable because of their wider distribution in direction of gravity and lower interpatient variability. Recently ropivacaine has been marketed in India as a hyperbaric solution. The effect of 0.75% ropivacaine hyperbaric in comparison to 0.5% bupivacaine hyperbaric is, however is not evaluated much to firmly claim the advantages and disadvantages the drug ( one above the other)

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-19
• Study Start: 2023-02-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Age 18- 60 years ,ASA 1 and 2 both male and female, duration of surgery.
• minimum 1 hr.

Exclusion Criteria

Patients with contraindication to spinal anaesthesia, allergy to drug being used, patient with neurological deficit, pregnancy women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time of onset of sensory block, time taken to achieve T10 segment sensory block, maximum height of block, time to 2 segment regression and complete sensory recovery. Onset of motor block, time taken to achieve complete motor block, complete motor recovery	0, 2, 4, 6, 8, 10, 12, 14, 20, 25, 30, 40, 50, 60, 90, 120 min, time till requirement of rescue analgesia

Secondary Outcome Measures

Name	Time	Method
Heart rate, non invasive blood pressure, peripheral oxygen saturation , any adverse effects	0, 2, 4, 6, 8, 10, 12, 14, 20, 25, 30, 40, 50, 60, 90, 120 min, time till patients shifted to ward from postoperative unit.

Trial Locations

Locations (1)

AIIMS Raipur; 🇮🇳 Raipur, CHHATTISGARH, India

AIIMS Raipur

🇮🇳Raipur, CHHATTISGARH, India

Dr Jitendra kalbande

Principal investigator

08368326094

drjitu222@gmail.com