Evaluation of serum level of Interleukin 4, Interleukin 6 in patients with major depressive disorder considering history of suicide attempts in a tertiary care hospital of Eastern India – A cross sectional study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- To find out the link between serum IL 6, IL 4 and psychosocial variables in suicide attempts
研究概览
简要总结
Patient suffering from Major Depressive Disorder (MDD) with a history of suicide attempts attending the in and outpatient department
of Psychiatry of R G kar Medical College & Hospital, having given proper consent and fulfilling
inclusion and exclusion criteria are taken into the study. Patients will be assessed using Mini International
Neuropsychiatric Interview (M.I.N.I). Depressive symptoms will be evaluated using the Public Health
Questionnaire (PHQ-9), Hamilton Depression Rating Scale (HDRS). Suicide attempts will be
assessed by the Pierce Suicide Intent Scale. Serum IL 4 and IL 6 will be measured by ELISA technique.
Descriptive statistics will be utilized for the expression of data. The P value of< 0.05 will be considered
statistically significant at a 95 confidence interval. All the analysis will be done by using the SPSS version
27, Graphpad prism etc
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient of age above 18 years suffering from major depressive disorder with a history of suicide attempts.
- •Patients who will give informed consent for the study.
排除标准
- •Patients who disagree to give consent.
- •Patients with a history of substance abuse except tobacco and alcohol.
- •Any chronic condition with cognitive dysfunction.
- •Clinical history of systemic autoimmune disease.
- •Patients receiving recent (last week) anti-inflammatory medication.
- •Patients with severe injuries will not be recruited in the first month following suicide attempts (They will not be considered as a recent suicide attempt group).
结局指标
主要结局
To find out the link between serum IL 6, IL 4 and psychosocial variables in suicide attempts
时间窗: Baseline
次要结局
- 1. To enquire for the correlation between serum IL 6, IL 4 and major depressive disorder (MDD)
研究者
Gunjan Gayen
R G Kar Medical College and Hospital