Mixed Plant- vs. Animal-based Supplementary Protein to Support Muscle Adaptations to Resistance Exercise: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- vastus lateralis muscle cross sectional area
研究概览
简要总结
This is a randomized controlled trial aimed to investigate the effects of different supplementary protein sources on muscle adaptations to resistance exercise. Young, healthy, recreationally active participants consuming an omnivorous diet with protein intake within recommended dietary allowance (RDA) (i.e.; 0.8-1.0 g.kg-1. d-1) will be recruited to undergo a 12-wk supervised resistance training program in combination with the intake of three 15-g daily doses (45g. d-1 total) of either a mixed plant- (i.e.; soy and pea protein) or animal-based (i.e.; whey protein) protein in drink form as a supplementary source of protein to their main meals of the day (i.e.; breakfast, lunch, and dinner). Before (PRE) and after (POST) the 12-wk intervention, participants will be assessed for body composition by dual-energy X-ray absorptiometry (DXA), muscle cross-sectional area (ultrasound) and fiber cross-sectional area (muscle biopsy), and maximal isotonic strength (1RM). Training consists of a resistance training (RT) program individually supervised by a researcher blinded to treatment in a laboratorial setting. Assessments will also be conducted in a blinded fashion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Physically active (according to the International Physical Activity Questionnaire (IPAQ)
- •Absence of any chronic condition that could preclude participation in a RT program or physical testing
- •Habitual protein consumption within RDA ≥ 0.8 ≤1.0 g.kg-
排除标准
- •Prior history of anabolic steroids use, current or previous (≤ 3 m)
- •Use of ergogenic or protein-based supplements, current or previous (< 1 y)
- •Engagement in energy-restricted diets
研究组 & 干预措施
animal protein
Whey protein will be used as the active comparator for animal protein arm
干预措施: Animal protein (Dietary Supplement)
plant protein
A combination of pea and soy protein will be used as the experimental arm
干预措施: Plant Protein (Dietary Supplement)
结局指标
主要结局
vastus lateralis muscle cross sectional area
时间窗: Ultrasound images will be obtained both at baseline (before the comencement of the study) and immediately after the 12-week intervention period
the investigators used ultrasound measures of the vastus lateralis cross sectional area as the primary outcome
次要结局
- lean mass(DXA scans will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period)
- fiber cross sectional area(Fiber cross sectional areas will be measured both at baseline (before the comencement of the study) and immediately after the 12-week intervention period)
- maximal isotonic strength(1-RM tests will be taken both at baseline (before the comencement of the study) and immediately after the 12-week intervention period)
研究者
Hamilton Augusto Roschel da Silva
Doctor of Philosophy
University of Sao Paulo General Hospital