ongitudinal study of aerobic capacity and skeletal muscle characteristics in patients with rare inherited metabolic disorders

ottingham Trent University0 个研究点目标入组 100 人开始时间: 2022年5月3日最近更新: 2022年5月30日

适应症

试验速览

暂无简介。

•Adult patients (=18 years) with a diagnosis of a rare inherited disorder of metabolism including glycogen storage disease, fatty acid oxidation disorder and phenylketonuria

•1. Individuals who do not have the capacity to consent
•2. Pregnancy
•3. Individuals with contraindications to exercise testing, as stated by the American College of Cardiology/American Heart Association Guidelines for Exercise Testing included below:
•3.1. Acute myocardial infarction (within 2 days)
•3.2. High-risk unstable angina
•3.3. Uncontrolled cardiac arrhythmias causing symptoms or hemodynamic compromise
•3.4. Symptomatic severe aortic stenosis
•3.5. Uncontrolled symptomatic heart failure
•3.6. Acute pulmonary embolus or pulmonary infarction
•3.7. Acute myocarditis or pericarditis
•3.8. Acute aortic dissection Relative
•3.9. Left main coronary stenosis
•3.10. Moderate stenotic valvular heart disease
•3.11. Electrolyte abnormalities
•3.12. Severe arterial hypertension
•3.13. Tachyarrhythmias or bradyarrhythmias
•3.14. Hypertrophic cardiomyopathy and other forms of outflow tract obstruction
•3.15. Mental or physical impairment leading to inability to exercise adequately
•3.16. High-degree atrioventricular block

发起方

ottingham Trent University