Therapeutic effects of Magnesium Sulfate (MgSO4) in acute organophosphate pesticide poisoning
- Conditions
- Acute organophosphate pesticide posoning.Organophosphate and carbamate insecticides
- Registration Number
- IRCT201104272083N3
- Lead Sponsor
- Vice-chancellor for research- Mashhad University of Medical Sciences, Mashhad, Iran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Determined acute moderate to severe organophosphate poisoning ; filling the written informed consent by the patients or close relatives in cases with diminished consciousness.
Exclusion criteria: disinclination to continue ; age of below 10 years or above 60 years old; mild organophosphate poisoning ; history of severe diseases such as heart, lung,renal or hepatic insufficiency, and metabolic diseases ; simultaneous poisoning with other chemicals ; history of epilepsy prior to the poisoning ; passing more than 24 hours after the consumption ; occurring of primary signs and symptoms of Mg poisoning in case group ; ECG changes that require different dose of MgSO4 administration or any other interfering drug
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method RBC Cholinesterase level. Timepoint: prior to the treatment and daily. Method of measurement: blood sample.;ICU admission. Timepoint: after the intervention. Method of measurement: Number of days during ICU admission.;Mechanical ventilation. Timepoint: after the intervention. Method of measurement: number of days within the patient needs mechanical ventilation.;Patients' mortality. Timepoint: after the intervention. Method of measurement: observation.;Post-loading maintenance doses of atropine. Timepoint: at the beginning and at the end of patient's admission. Method of measurement: sum of maintenance of atropine in each day of admission (mg).
- Secondary Outcome Measures
Name Time Method Diminished respiratory rate as a complication of MgSO4 infusion. Timepoint: continuously from the beginning of the infusion. Method of measurement: cardiac monitoring.;Diminished deep tendon reflexes as a complication of MgSO4 infusion. Timepoint: each 5 minutes from the beginning of the infusion. Method of measurement: physical examination.;Hypotension as a complication of MgSO4 infusion. Timepoint: continuously from the beginning of the infusion. Method of measurement: cardiac monitoring.