Comparison of the Effect of MCFA and LCFA on Postprandial Appetite and Lipemia
- Conditions
- Lipemia
- Interventions
- Dietary Supplement: Palm oilDietary Supplement: Coconut oil
- Registration Number
- NCT05539742
- Lead Sponsor
- University of Jordan
- Brief Summary
The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).
- Detailed Description
Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of postprandial triglyceride production and clearance in the blood, as well as the appetite, are influenced by the quality of the food consumed, such as the length of saturated fatty acids. The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both sexes and it will be conducted at the University of Jordan. The study will involve two experimental test days, each separated by at least a week of washout interval, and each test day will last for 6 hours. All subjects will be randomly assigned to one of the experimental meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles \[total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)\] will be examined in a private lab. After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
- Age between 18-50 years
- Males and females
- Apparently healthy
- Fasting triglyceride (TG) < 2.5 mmol/L or 222 mg/dl at the time of screening.
- Body mass index (BMI) in normal range (18.5-24.9).
- Stable weight for at least 3 months
- Consumption of lipid-lowering drugs or any medication that might affect appetite.
- Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month.
- Regular consumption of two or more fish meals a week over the previous month.
- A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease.
- Current smokers
- Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS)
- Athlete
- Being on a diet or lifestyle changes for the past month.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Palm oil Palm oil The palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval. Coconut oil Coconut oil The coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval.
- Primary Outcome Measures
Name Time Method Anthropometric measurements (percentage body fat) baseline, pre-intervention,1 day for each participant /during 3 months Bioelectrical impedance will be used to determine body composition
Dietary intake (3-days food record) one day Participants will be asked to fill out a food record to track changes in their (intake) appetite
Anthropometric measurements ( Height) baseline, pre-intervention, 1 day for each participant /during 3 months Standing height, without footwear, will be taken using stadiometer to the nearest 5mm
Anthropometric measurements (Weight) baseline, pre-intervention, 1 day for each participant /during 3 months Bioelectrical impedance will be used to determine body weight
Anthropometric measurements (waist circumference) baseline, pre-intervention, 1 day for each participant /during 3 months Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm
Biochemical measurements (Total cholesterol (TC)) After the intervention / up to 3 months from collecting the samples Up to 6 hours
Biochemical measurements (Low density lipoprotein cholesterol (LDL)) Up to 6 hours Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Biochemical measurements ( High density lipoprotein cholesterol (HDL)) Up to 6 hours High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Biochemical measurements (Triglyceride (TG)) Up to 6 hours Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The University of Jordan
🇯🇴Amman, Jordan