Prevalence of Liver Fibrosis and Progression of Liver Fibrosis

• Conditions: HIV Infection and Chronic Alanine Aminotransferase Elevation

• Registration Number: NCT01208376
• Lead Sponsor: Helen Kovari-Kramer

Brief Summary

Little is known about the clinical significance of chronic alanine aminotransferase (ALT) elevation in HIV-infected patients without hepatitis B and C coinfection. Study aim is first to evaluate the prevalence of liver fibrosis and cirrhosis in HIV-infected patients with chronic ALT elevation and no chronic viral hepatitis using non-invasive diagnostic tests and second to find associated factors with significant fibrosis and cirrhosis. In a second longitudinal part we intend to assess fibrosis progression within 1 and 3 years.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-09-22
• Study First Submitted QC: 2010-09-22
• Study First Posted: 2010-09-23
• Study Start: 2010-10
• Status Verified: 2016-05
• Last Update Submitted: 2016-12-19
• Last Update Posted: 2016-12-20
• Primary Completion: 2018-08
• Study Completion: 2018-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 195

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Liverfibrosis	3 years

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, Switzerland