Comparison of Plasma Orexin-A Levels and Awakening Time From Anesthesia in Patients With and Without Insomnia Who Had Laparoscopic Cholecystectomy Under General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Orexin-A Levels
研究概览
简要总结
In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.
详细描述
ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male patients undergo elective laparoscopic cholecystectomy under general anesthesia
- •Between 18-65 age
排除标准
- •Patients with obstructive sleep apnea syndrome
- •Bleeding over 500 ml
- •Allergic to anesthetic agents
- •Patients with a BMI > 30 kg/m2
结局指标
主要结局
Orexin-A Levels
时间窗: at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation
plasma OXA levels anesthesia induction and after anesthesia in control group
次要结局
- recovery time from general anesthesia(time of eyes opening and time of extubation)
研究者
Melike Korkmaz Toker
Associate Professor of Anesthesiology and Reanimation
Muğla Sıtkı Koçman University