Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Telomere length of circulating leukocytes
研究概览
简要总结
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men aged 20 to 65 years
- •Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil
- •With an AHI > 5 / h
- •Healthy volunteers:
- •Men aged 20 to 65 years
- •With an AHI ≤ 5 / h
排除标准
- •All subjects:
- •Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated,
- •Known cardiovascular disease associated (heart failure, rhythm disorder ...)
- •Known respiratory diseases
- •Known neoplastic pathology, known chronic inflammatory disease
- •Psychiatric pathology treated
- •Medication
- •Not affiliated to the French social health care system
- •Major protected person
- •Private person of liberty
- •People in emergency situation
- •Patient refusing to participate in the study
研究组 & 干预措施
Severe OSA
Patients with severe OSA (AHI > 30)
干预措施: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations (Other)
Moderate OSA
Patients with moderate OSA (5 < AHI ≤ 30)
干预措施: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations (Other)
Healthy volunteers
Healthy volunteers (AHI ≤ 5)
干预措施: Polysomnography , blood collection, bone densitometry and Functional respiratory explorations (Other)
结局指标
主要结局
Telomere length of circulating leukocytes
时间窗: 4 weeks
次要结局
- Carotid-femoral pulse wave velocity(4 weeks)
- Markers of oxidative stress: Malondialdehyde, heme oxygenase-1(4 weeks)
- Markers of growth hormone axis (GH, IGF-1, IGFBP)(4 weeks)
- Bone density(4 weeks)
- Correlation between biological parameters and neuropsychological assessment(4 weeks)
- Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1(4 weeks)