Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.

Not Applicable

Completed

• Conditions: Obstructive Sleep Apnea

• Registration Number: NCT02876653
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2016-07
• Study First Submitted: 2016-07-31
• Study First Submitted QC: 2016-08-18
• Last Update Submitted: 2016-08-18
• Study First Posted: 2016-08-24
• Last Update Posted: 2016-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 53

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Telomere length of circulating leukocytes	4 weeks

Secondary Outcome Measures

Name	Time	Method
Markers of oxidative stress: Malondialdehyde, heme oxygenase-1	4 weeks
Markers of growth hormone axis (GH, IGF-1, IGFBP)	4 weeks
Bone density	4 weeks
Correlation between biological parameters and neuropsychological assessment	4 weeks
Markers of inflammation: hs-CRP, IL-6, IL-8, MCP-1	4 weeks
Carotid-femoral pulse wave velocity	4 weeks

Trial Locations

Locations (1)

Henri Mondor Hospital; 🇫🇷 Creteil, France