A prospective observational study for the diagnosis of non-alcoholic fatty liver disease with circulating natriuretic peptides
- Conditions
- on-alcoholic fatty liver disease
- Registration Number
- JPRN-UMIN000048569
- Lead Sponsor
- Sapporo Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 500
Not provided
1. Patients with a history diagnosed or treated with heart failure 2. Patients with alcohol intake (ethanol conversion) of 30g/day for males and 20g/day for females 3. Patients diagnosed with liver cirrhosis 4. Patients who have a history of infection or who are treated with hepatitis B or hepatitis C 5. Patients with intrahepatic malignant tumors such as hepatocellular carcinoma 6. Patients with a diagnosis of any malignancy 7. Patients under treatment with steroids, immunosuppressants, anticancer drugs, etc. 8. Patients diagnosed with chronic inflammatory diseases, such as autoimmune hepatitis, inflammatory bowel disease 9. Patients who do not consent to this study 10. Patients who are judged to be inappropriate as research subjects by the research director
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlation between the degree of hepatic steatosis/fibrosis by abdominal ultrasound and plasma ANP or BNP concentration
- Secondary Outcome Measures
Name Time Method 1. Comparison of the diagnostic accuracy of liver fibrosis between the conventional scoring system to predict liver fibrosis (Fib-4 index, NAFLD fibrosis score) and plasma ANP or BNP concentration 2. Correlation between the presence or absence of arteriosclerosis diagnosed by ABI (ankle brachial pressure index) and plasma ANP/BNP concentrations 3. Correlation between liver fibrosis, arteriosclerosis, and RAS/fibrosis/inflammatory biomarkers