The Multi-center Study of Percutaneous Focal Liver Lesions Biopsy Guided by Contrast-Enhanced Ultrasound
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Neoplasms
- Sponsor
- Peking University Cancer Hospital & Institute
- Enrollment
- 2088
- Locations
- 1
- Primary Endpoint
- diagnostic accuracy
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to estimate the clinical value of contrast-enhanced ultrasound in percutaneous biopsy for liver occupied lesion.
Detailed Description
The patients with liver neoplasms who need receive percutaneous biopsy were randomized into contrast-enhanced ultrasound(CEUS) group and conventional ultrasound(US) group.The aims include: 1. Comparison the diagnostic accuracy rate, specificity and sensitivity between CEUS and US group. 2. Comparison the diagnostic accuracy rate specificity and sensitivity between smaller(\<3cm) and larger(≥3cm) nodule group. 3. To explore operating strategy of contrast-enhanced ultrasound guided biopsy. 4. To evaluate economic efficiency of contrast-enhanced ultrasound guided biopsy compared with conventional ultrasound guided biopsy.
Investigators
Kun Yan
Beijing Cancer Hospital
Peking University Cancer Hospital & Institute
Eligibility Criteria
Inclusion Criteria
- •patients with liver occupied lesion who cannot be diagnosed by imaging examination or need pathological results
Exclusion Criteria
- •severe anemia
- •PLT\<60000/mm3,prothrombin activityprothrombin time activity\<70%
- •women during menstruation, pregnancy, child birth and baby nursing period
- •patients with severe mental disorder
- •cardiopulmonary failure
Outcomes
Primary Outcomes
diagnostic accuracy
Time Frame: 12 months
diagnostic accuracy=（true positive+ ture negative)/number of parcitipants