Assessment of Composite Inflammatory Ratios in Juvenile Idiopathic Arthritis and Their Association With Disease Activity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 主要终点
- possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis
研究概览
简要总结
Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who classified JIA according to International League of Associations for Rheumatology ILAR criteria on treatment with exclusion of systemic JIA.
- •Patients with disease duration more than 6 months.
- •Age below 16 years old.
- •Patient cooperative and can answer questions.
- •Patients who are able and willing to give written informed consent or their parents/guardians
排除标准
- •Systemic JIA.
- •Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks.
- •Patients who are not able and willing to give written informed consent
结局指标
主要结局
possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis
时间窗: 6 months
possibility to detect systemic inflammatory index and its relation to disease activity and risk of flare in juvenile idiopathic arthritis
时间窗: 6 months
assessment of activity of disease according to JDAS SCORE
时间窗: 6 months
assessment of neutrophils to albumin ratio and its relation to JDAS score activity score
时间窗: 6 months
次要结局
未报告次要终点
研究者
Hadeer Fadlalmawla Mohamed
resident at rheumatology and rehabilitation department at sohag university hospitals
Sohag University