Assessment of Composite Inflammatory Ratios in Juvenile Idiopathic Arthritis and Their Association With Disease Activity
- Conditions
- Juvenile Idiopathic Arthritis
- Registration Number
- NCT07083466
- Lead Sponsor
- Sohag University
- Brief Summary
Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 90
-
Patients who classified JIA according to International League of Associations for Rheumatology ILAR criteria on treatment with exclusion of systemic JIA.
-
Patients with disease duration more than 6 months. 3. Age below 16 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent or their parents/guardians
-
- Systemic JIA. 2. Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks.
Patients who are not able and willing to give written informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis 6 months possibility to detect systemic inflammatory index and its relation to disease activity and risk of flare in juvenile idiopathic arthritis 6 months assessment of activity of disease according to JDAS SCORE 6 months assessment of neutrophils to albumin ratio and its relation to JDAS score activity score 6 months
- Secondary Outcome Measures
Name Time Method